Detailed information NTG0513269

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6G42_RS01935
• Genome accession: NZ_CP065707
• Coordinates: 400472..401224 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866081.1
• Uniprot ID: A0A428BMV3
• Organism: Streptococcus oralis strain FDAARGOS_885
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 395472..406224

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G42_RS01915 (I6G42_01915)	-	396923..399565 (-)	2643	WP_038804777.1	YhgE/Pip domain-containing protein	-
I6G42_RS01920 (I6G42_01920)	-	399694..400236 (+)	543	WP_038804778.1	TetR/AcrR family transcriptional regulator	-
I6G42_RS01935 (I6G42_01935)	comE	400472..401224 (-)	753	WP_000866081.1	competence system response regulator transcription factor ComE	Regulator
I6G42_RS01940 (I6G42_01940)	comD	401221..402540 (-)	1320	WP_038804779.1	competence system sensor histidine kinase ComD	Regulator
I6G42_RS01945 (I6G42_01945)	comC	402562..402687 (-)	126	WP_000799680.1	competence-stimulating peptide ComC	Regulator
I6G42_RS01955 (I6G42_01955)	rlmH	402971..403450 (-)	480	WP_038804781.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6G42_RS01960 (I6G42_01960)	htrA	403634..404824 (+)	1191	WP_038804782.1	S1C family serine protease	Regulator
I6G42_RS01965 (I6G42_01965)	spo0J	404882..405640 (+)	759	WP_038804784.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29920.29 Da
• Isoelectric Point: 6.9820

>NTDB_id=513269 I6G42_RS01935 WP_000866081.1 400472..401224(-) (comE) [Streptococcus oralis strain FDAARGOS_885]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKTKK

Nucleotide

• Length: 753 bp

>NTDB_id=513269 I6G42_RS01935 WP_000866081.1 400472..401224(-) (comE) [Streptococcus oralis strain FDAARGOS_885]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCGGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCACGGAATTGAGAAAAAGGGCTTTGAAGTGGCACAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACAACAGGTGTTTCTCATAAACTGCGGATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACCATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATCAATATTGGAAATGTTAGAG
AAATTGATCGAAAGAATCTAGAAGTTGTCTTTTATGAAGATCATCGCTGCCCCATCACTCGTTTGAAAGTTCGTAAACTG
AAAGATATTCTAGAGAAAAAAACTAAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A428BMV3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96	100	0.96
comE	Streptococcus mitis SK321	95.2	100	0.952
comE	Streptococcus pneumoniae Rx1	94.4	100	0.944
comE	Streptococcus pneumoniae D39	94.4	100	0.944
comE	Streptococcus pneumoniae R6	94.4	100	0.944
comE	Streptococcus pneumoniae TIGR4	94.4	100	0.944
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	40.081	98.8	0.396