Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6G42_RS01960 Genome accession   NZ_CP065707
Coordinates   403634..404824 (+) Length   396 a.a.
NCBI ID   WP_038804782.1    Uniprot ID   A0A3R9J4C1
Organism   Streptococcus oralis strain FDAARGOS_885     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 398634..409824
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G42_RS01920 (I6G42_01920) - 399694..400236 (+) 543 WP_038804778.1 TetR/AcrR family transcriptional regulator -
  I6G42_RS01935 (I6G42_01935) comE 400472..401224 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  I6G42_RS01940 (I6G42_01940) comD 401221..402540 (-) 1320 WP_038804779.1 competence system sensor histidine kinase ComD Regulator
  I6G42_RS01945 (I6G42_01945) comC 402562..402687 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  I6G42_RS01955 (I6G42_01955) rlmH 402971..403450 (-) 480 WP_038804781.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6G42_RS01960 (I6G42_01960) htrA 403634..404824 (+) 1191 WP_038804782.1 S1C family serine protease Regulator
  I6G42_RS01965 (I6G42_01965) spo0J 404882..405640 (+) 759 WP_038804784.1 ParB/RepB/Spo0J family partition protein Regulator
  I6G42_RS01970 (I6G42_01970) dnaA 405864..407225 (+) 1362 WP_038804785.1 chromosomal replication initiator protein DnaA -
  I6G42_RS01975 (I6G42_01975) dnaN 407384..408520 (+) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  I6G42_RS01980 (I6G42_01980) - 408585..408779 (+) 195 WP_038804786.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41784.70 Da        Isoelectric Point: 6.8886

>NTDB_id=513272 I6G42_RS01960 WP_038804782.1 403634..404824(+) (htrA) [Streptococcus oralis strain FDAARGOS_885]
MKHLQTFYKKGVTFLIIILIGFLSGALGSFVTLQLYQKQGNQATNNTTNTVTQTSYKNENATTQAVNKVKDAVVSVITYS
ANRQNSVFGNDETDTDTDSQQVASEGSGVIYKKNGKDAYLVTNTHVIKGASKVDIRLADGTKVPGEIVGSDTFSDIAVVK
ISSEKVTTVAEFGDSSKLNVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSQDGQAISTKAIQTDTAINPGNSGGP
LVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLANIGASDLRKLNIPSSVTS
GVVVKSVQSNMPASGHLEKYDVITKVDDKNISSSTDLQSALYNHSIGDTIKITYYRNGKEETTTVKLDKSTSDLES

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=513272 I6G42_RS01960 WP_038804782.1 403634..404824(+) (htrA) [Streptococcus oralis strain FDAARGOS_885]
ATGAAACACTTACAAACATTTTACAAAAAAGGAGTTACCTTTCTTATCATCATTCTGATAGGATTTTTGAGTGGAGCCTT
GGGAAGTTTTGTAACATTGCAGCTTTATCAGAAACAAGGAAATCAAGCTACAAATAACACTACAAACACTGTTACTCAGA
CTTCCTACAAAAATGAAAATGCAACAACTCAGGCCGTTAATAAGGTAAAAGATGCCGTTGTGTCGGTTATCACTTATTCA
GCAAATCGGCAAAATAGTGTTTTTGGAAATGACGAGACAGATACGGATACCGACTCTCAACAGGTAGCAAGTGAAGGTTC
TGGTGTTATTTACAAAAAGAATGGGAAAGATGCCTACCTTGTGACAAATACCCACGTTATTAAAGGAGCTTCAAAAGTTG
ATATCCGTTTAGCAGACGGTACAAAAGTTCCTGGTGAAATTGTCGGTTCTGATACGTTCTCTGATATTGCTGTCGTAAAA
ATTTCTTCAGAAAAAGTCACAACCGTAGCAGAATTTGGAGATTCTAGCAAACTAAATGTTGGTGAGACTGCAATCGCAAT
TGGTAGTCCTCTAGGATCAGAATATGCCAATACAGTTACCCAAGGAATCATTTCAAGTCTCAATCGAAATGTCTCTCTAA
AATCTCAAGATGGTCAAGCGATTTCTACAAAAGCTATTCAGACAGATACGGCCATTAACCCTGGTAACTCTGGTGGTCCA
CTGGTAAATATTCAAGGACAAGTCATCGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACCTCTGTCGAAGGTCT
TGGTTTTGCAATCCCATCAAATGATGCTCAAAATATTATTAAACAGCTTGAAAGTGACGGTAAAGTGACTCGCCCTGCTC
TTGGAATTCAAATGGTTAATTTAGCTAATATCGGAGCTAGTGATCTTAGAAAACTCAATATTCCAAGTAGCGTAACTTCT
GGTGTAGTGGTAAAATCTGTTCAAAGTAATATGCCTGCATCTGGTCACCTTGAAAAATACGACGTTATTACCAAAGTTGA
CGACAAGAATATTTCTTCGTCAACAGATTTACAGAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAAATTACCT
ACTATCGAAATGGGAAAGAGGAGACTACAACTGTTAAGCTAGATAAAAGTACAAGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(106-251)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3R9J4C1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

84.848

100

0.848
  htrA Streptococcus pneumoniae Rx1

83.333

100

0.833
  htrA Streptococcus pneumoniae D39

83.333

100

0.833
  htrA Streptococcus pneumoniae R6

83.333

100

0.833
  htrA Streptococcus pneumoniae TIGR4

83.333

100

0.833
  htrA Streptococcus gordonii str. Challis substr. CH1

66.25

100

0.669
  htrA Streptococcus mutans UA159

54.887

100

0.553