Detailed information NTG0513181

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6G43_RS00805
• Genome accession: NZ_CP065706
• Coordinates: 174719..175471 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866081.1
• Uniprot ID: A0A428BMV3
• Organism: Streptococcus oralis strain FDAARGOS_886
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 169719..180471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G43_RS00785 (I6G43_00785)	-	171154..173808 (-)	2655	WP_038805924.1	YhgE/Pip domain-containing protein	-
I6G43_RS00790 (I6G43_00790)	-	173937..174479 (+)	543	WP_000665074.1	TetR/AcrR family transcriptional regulator	-
I6G43_RS00805 (I6G43_00805)	comE	174719..175471 (-)	753	WP_000866081.1	competence system response regulator transcription factor ComE	Regulator
I6G43_RS00810 (I6G43_00810)	comD	175468..176787 (-)	1320	WP_001048119.1	competence system sensor histidine kinase ComD	Regulator
I6G43_RS00815 (I6G43_00815)	comC	176809..176934 (-)	126	WP_000799680.1	competence-stimulating peptide ComC	Regulator
I6G43_RS00825 (I6G43_00825)	rlmH	177218..177697 (-)	480	WP_000694218.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6G43_RS00830 (I6G43_00830)	htrA	177882..179072 (+)	1191	WP_000681799.1	S1C family serine protease	Regulator
I6G43_RS00835 (I6G43_00835)	spo0J	179130..179888 (+)	759	WP_000410355.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29920.29 Da
• Isoelectric Point: 6.9820

>NTDB_id=513181 I6G43_RS00805 WP_000866081.1 174719..175471(-) (comE) [Streptococcus oralis strain FDAARGOS_886]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKTKK

Nucleotide

• Length: 753 bp

>NTDB_id=513181 I6G43_RS00805 WP_000866081.1 174719..175471(-) (comE) [Streptococcus oralis strain FDAARGOS_886]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTTGAGAGAATATTGAATGAAATCTCTGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCACGGGATTGAGAAAAAGGGATTTGAAGTGGCACAGTTTATCCGTCATCACAATCCC
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTATAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACAACAGGTGTTTCTCATAAACTGCGAATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACCATGACAGA
TATTCAGGAGAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATTAATATTGGAAATGTGAGAG
AAATTGATCGAAAGAATCTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAAACTAAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A428BMV3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96	100	0.96
comE	Streptococcus mitis SK321	95.2	100	0.952
comE	Streptococcus pneumoniae Rx1	94.4	100	0.944
comE	Streptococcus pneumoniae D39	94.4	100	0.944
comE	Streptococcus pneumoniae R6	94.4	100	0.944
comE	Streptococcus pneumoniae TIGR4	94.4	100	0.944
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	40.081	98.8	0.396