Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   I6G43_RS00810 Genome accession   NZ_CP065706
Coordinates   175468..176787 (-) Length   439 a.a.
NCBI ID   WP_001048119.1    Uniprot ID   A0A7T2ZNP3
Organism   Streptococcus oralis strain FDAARGOS_886     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 170468..181787
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G43_RS00785 (I6G43_00785) - 171154..173808 (-) 2655 WP_038805924.1 YhgE/Pip domain-containing protein -
  I6G43_RS00790 (I6G43_00790) - 173937..174479 (+) 543 WP_000665074.1 TetR/AcrR family transcriptional regulator -
  I6G43_RS00805 (I6G43_00805) comE 174719..175471 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  I6G43_RS00810 (I6G43_00810) comD 175468..176787 (-) 1320 WP_001048119.1 competence system sensor histidine kinase ComD Regulator
  I6G43_RS00815 (I6G43_00815) comC 176809..176934 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  I6G43_RS00825 (I6G43_00825) rlmH 177218..177697 (-) 480 WP_000694218.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6G43_RS00830 (I6G43_00830) htrA 177882..179072 (+) 1191 WP_000681799.1 S1C family serine protease Regulator
  I6G43_RS00835 (I6G43_00835) spo0J 179130..179888 (+) 759 WP_000410355.1 ParB/RepB/Spo0J family partition protein Regulator
  I6G43_RS00840 (I6G43_00840) dnaA 180112..181473 (+) 1362 WP_000660603.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51333.02 Da        Isoelectric Point: 5.3406

>NTDB_id=513182 I6G43_RS00810 WP_001048119.1 175468..176787(-) (comD) [Streptococcus oralis strain FDAARGOS_886]
MNLFGLVIAFFYVFIISKIYEWTCNATKKEKYIYSLYVFLLQLILEEIMYLLALDGYGLSKFLFPLLIFGYFVGFQKYDK
SKGVFISLLFSLLYHSSNNFISVTLSSITGDDIALEYNNYFIIFVLILTYLVIKIVISYFHLEFKYFDKEYLYSFLKKVL
YAFIFLHIVSFISDIVSTISHLNSFGSILSTIVFICLLLIFFAMNSYKVQIEKEIALKQKKFEQKHLQTYTDEIVKLYNE
IRGFRHDYAGMLVSMQMAIDSEDLQEIDRVYNEVLVKANQKLRSEKYTYFDLNNLEDSALRSLIAQSIVYARNNDVEFTL
EVKDVITRLSMDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIMLETEMEDSTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=513182 I6G43_RS00810 WP_001048119.1 175468..176787(-) (comD) [Streptococcus oralis strain FDAARGOS_886]
ATGAATTTATTTGGATTAGTAATAGCTTTTTTTTATGTTTTTATCATTAGTAAAATTTATGAATGGACTTGTAATGCAAC
TAAAAAAGAAAAATATATTTATAGTCTTTATGTCTTTTTACTACAATTAATATTAGAAGAAATAATGTATTTGCTAGCCT
TAGATGGTTACGGTTTGTCTAAATTTTTATTTCCTTTACTCATATTTGGTTACTTTGTTGGATTTCAGAAGTATGATAAG
TCTAAGGGAGTTTTTATAAGCCTATTATTTTCTCTCTTATATCATAGTAGTAATAACTTTATATCGGTAACTTTATCATC
TATAACAGGAGATGATATTGCATTAGAATATAATAATTATTTTATTATATTTGTACTTATTTTAACCTATTTGGTTATTA
AAATTGTCATATCTTATTTCCATTTGGAGTTTAAATATTTTGACAAAGAATATCTCTATTCTTTTTTGAAAAAAGTACTA
TATGCATTTATCTTCTTGCATATCGTCTCTTTTATTTCAGATATCGTGAGTACTATTTCTCATTTAAATAGTTTTGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTTATAAGGTTCAAATTGAAAAAG
AGATTGCCCTAAAGCAGAAGAAATTTGAACAAAAGCATTTACAGACTTATACTGATGAAATTGTCAAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGTATGCTTGTCAGCATGCAAATGGCAATTGACAGTGAAGATTTACAGGAAAT
TGACAGAGTTTACAATGAAGTATTAGTAAAAGCGAATCAAAAACTGCGTTCAGAAAAATATACTTACTTTGATTTGAACA
ATTTAGAAGATTCAGCTTTACGTAGTTTGATTGCTCAATCCATTGTTTATGCACGAAATAATGATGTAGAGTTTACATTG
GAAGTAAAGGATGTTATTACTAGATTGTCAATGGATTTACTTGATCTTGTTCGCATCATGAGTATTCTCTTAAACAATGC
TGTTGAAGGAGCCGCGGATAGTTACTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAGACAGTTATAGTCA
TCCAGAATTCATGTAAAATCACTATGACGCCTTCAGAGGACTTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTTTAGGGCTTAATAATGTCAAAGAGATTCTAGATAAATATGACAACATTATGTTAGAAACAGAGATGGAAGACAGCAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(332-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZNP3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis SK321

72.789

100

0.731
  comD Streptococcus mitis NCTC 12261

72.562

100

0.729
  comD/comD2 Streptococcus pneumoniae TIGR4

71.429

100

0.718
  comD/comD1 Streptococcus pneumoniae R6

70.975

100

0.713
  comD/comD1 Streptococcus pneumoniae Rx1

70.975

100

0.713
  comD/comD1 Streptococcus pneumoniae D39

70.975

100

0.713
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.404

85.649

0.415
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

48.128

85.194

0.41