Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC   Type   Regulator
Locus tag   I6G43_RS00815 Genome accession   NZ_CP065706
Coordinates   176809..176934 (-) Length   41 a.a.
NCBI ID   WP_000799680.1    Uniprot ID   A0A428FUE9
Organism   Streptococcus oralis strain FDAARGOS_886     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 171809..181934
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G43_RS00790 (I6G43_00790) - 173937..174479 (+) 543 WP_000665074.1 TetR/AcrR family transcriptional regulator -
  I6G43_RS00805 (I6G43_00805) comE 174719..175471 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  I6G43_RS00810 (I6G43_00810) comD 175468..176787 (-) 1320 WP_001048119.1 competence system sensor histidine kinase ComD Regulator
  I6G43_RS00815 (I6G43_00815) comC 176809..176934 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  I6G43_RS00825 (I6G43_00825) rlmH 177218..177697 (-) 480 WP_000694218.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6G43_RS00830 (I6G43_00830) htrA 177882..179072 (+) 1191 WP_000681799.1 S1C family serine protease Regulator
  I6G43_RS00835 (I6G43_00835) spo0J 179130..179888 (+) 759 WP_000410355.1 ParB/RepB/Spo0J family partition protein Regulator
  I6G43_RS00840 (I6G43_00840) dnaA 180112..181473 (+) 1362 WP_000660603.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4998.87 Da        Isoelectric Point: 10.1884

>NTDB_id=513183 I6G43_RS00815 WP_000799680.1 176809..176934(-) (comC) [Streptococcus oralis strain FDAARGOS_886]
MKNTVKLEQFKEVTETELQEIRGGEWRIPELIRNLIFPKRK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=513183 I6G43_RS00815 WP_000799680.1 176809..176934(-) (comC) [Streptococcus oralis strain FDAARGOS_886]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAAACAGAATTGCAGGAGATTCGGGGTGGGGAATGGAG
AATTCCAGAATTAATACGTAATCTTATTTTTCCAAAAAGAAAATAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-27)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A428FUE9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC Streptococcus mitis SK321

58.537

100

0.585
  comC/comC2 Streptococcus pneumoniae A66

53.659

100

0.537
  comC/comC2 Streptococcus pneumoniae TIGR4

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae R6

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae G54

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae D39

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae Rx1

51.22

100

0.512
  comC Streptococcus mitis NCTC 12261

47.5

97.561

0.463
  comC/comC2 Streptococcus gordonii strain NCTC7865

43.243

90.244

0.39