Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6G43_RS00830 Genome accession   NZ_CP065706
Coordinates   177882..179072 (+) Length   396 a.a.
NCBI ID   WP_000681799.1    Uniprot ID   A0A7T2ZNH8
Organism   Streptococcus oralis strain FDAARGOS_886     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 172882..184072
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G43_RS00790 (I6G43_00790) - 173937..174479 (+) 543 WP_000665074.1 TetR/AcrR family transcriptional regulator -
  I6G43_RS00805 (I6G43_00805) comE 174719..175471 (-) 753 WP_000866081.1 competence system response regulator transcription factor ComE Regulator
  I6G43_RS00810 (I6G43_00810) comD 175468..176787 (-) 1320 WP_001048119.1 competence system sensor histidine kinase ComD Regulator
  I6G43_RS00815 (I6G43_00815) comC 176809..176934 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  I6G43_RS00825 (I6G43_00825) rlmH 177218..177697 (-) 480 WP_000694218.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6G43_RS00830 (I6G43_00830) htrA 177882..179072 (+) 1191 WP_000681799.1 S1C family serine protease Regulator
  I6G43_RS00835 (I6G43_00835) spo0J 179130..179888 (+) 759 WP_000410355.1 ParB/RepB/Spo0J family partition protein Regulator
  I6G43_RS00840 (I6G43_00840) dnaA 180112..181473 (+) 1362 WP_000660603.1 chromosomal replication initiator protein DnaA -
  I6G43_RS00845 (I6G43_00845) dnaN 181632..182768 (+) 1137 WP_000581140.1 DNA polymerase III subunit beta -
  I6G43_RS00850 (I6G43_00850) - 182833..183027 (+) 195 WP_000285184.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41889.88 Da        Isoelectric Point: 6.8893

>NTDB_id=513184 I6G43_RS00830 WP_000681799.1 177882..179072(+) (htrA) [Streptococcus oralis strain FDAARGOS_886]
MKHLQKFYKKGFTFLIIILIGFLSGALGSFVTLQLYQKQVSQATNNTTNTVTQTSYKNENATTQAVNKVKDAVVSVITYS
ANRQNSVFGNDETDTDTDSQQVASEGSGVIYKKNGKDAYLVTNTHVIKGASKVDIRLADGTKVPGEIVGSDTFSDIAVVK
ISSEKVTTVAEFGDSSKLNVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSQDGQAISTKAIQTDTAINPGNSGGP
LVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLANIGASDLRKLNIPSSVTS
GVVVKSVQSNMPASGHLEKYDVITKVDDKEISSSTDLQSALYNHSIGDTIKITYYRNGKEETTTVKLDKSTSDLES

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=513184 I6G43_RS00830 WP_000681799.1 177882..179072(+) (htrA) [Streptococcus oralis strain FDAARGOS_886]
ATGAAACACTTACAAAAATTTTACAAAAAAGGATTTACCTTTCTTATCATCATTCTGATAGGATTTTTGAGTGGTGCCCT
AGGAAGTTTTGTGACACTGCAACTTTATCAAAAACAAGTAAGTCAAGCCACAAATAACACTACAAACACTGTTACTCAGA
CTTCCTACAAAAATGAAAATGCAACAACTCAGGCCGTTAATAAGGTAAAAGATGCCGTTGTGTCGGTCATCACTTATTCA
GCAAATCGGCAAAATAGTGTTTTTGGAAATGACGAGACAGATACGGATACCGACTCTCAACAGGTAGCAAGTGAAGGTTC
TGGTGTTATTTACAAAAAGAATGGGAAAGATGCCTACCTTGTGACAAATACCCACGTTATTAAAGGAGCTTCAAAAGTTG
ATATCCGTTTAGCAGACGGTACAAAAGTTCCTGGTGAAATTGTCGGTTCTGATACGTTCTCTGATATTGCTGTCGTAAAA
ATTTCTTCAGAAAAAGTCACAACCGTAGCAGAATTTGGAGATTCTAGCAAACTAAATGTTGGTGAGACTGCAATCGCAAT
TGGTAGTCCTCTAGGATCCGAATATGCCAATACAGTTACCCAAGGAATCATTTCAAGTCTCAATCGAAATGTCTCTCTAA
AATCTCAAGATGGTCAAGCGATTTCTACAAAAGCTATTCAGACAGATACGGCCATTAACCCTGGTAACTCTGGTGGTCCA
CTTGTAAACATTCAGGGCCAAGTTATCGGGATTACATCAAGTAAAATTGCAAGTAATGGTGGAACCTCTGTCGAAGGTCT
TGGTTTTGCAATCCCATCAAATGATGCTCAAAATATTATTAAACAGCTTGAAAGTGACGGTAAAGTGACTCGCCCTGCTC
TTGGAATTCAAATGGTTAATTTAGCTAATATCGGAGCTAGTGATCTTAGAAAACTCAATATTCCAAGTAGCGTAACTTCT
GGTGTAGTGGTAAAATCTGTTCAAAGTAATATGCCTGCATCTGGTCACCTTGAAAAATACGACGTTATTACCAAAGTTGA
CGACAAGGAGATTTCTTCGTCAACAGATTTACAGAGTGCTCTTTACAACCATTCTATCGGAGACACTATTAAAATCACCT
ACTATCGAAATGGGAAAGAGGAGACTACAACTGTTAAACTAGATAAAAGTACAAGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(106-251)

PDZ domain (PDZ_2)

(292-387)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZNH8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

85.101

100

0.851
  htrA Streptococcus pneumoniae Rx1

83.838

100

0.838
  htrA Streptococcus pneumoniae D39

83.838

100

0.838
  htrA Streptococcus pneumoniae R6

83.838

100

0.838
  htrA Streptococcus pneumoniae TIGR4

83.838

100

0.838
  htrA Streptococcus gordonii str. Challis substr. CH1

65.829

100

0.662
  htrA Streptococcus mutans UA159

54.386

100

0.548