Detailed information NTG0510986

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: ST4021_RS08875
• Genome accession: NZ_CP065493
• Coordinates: 1717227..1717553 (-)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus strain 4021
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1712227..1722553

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4021_RS08830	-	1712493..1712831 (-)	339	WP_224103197.1	CPBP family intramembrane glutamic endopeptidase	-
ST4021_RS08835	-	1712875..1713150 (-)	276	WP_011681681.1	hypothetical protein	-
ST4021_RS08840 (ST4021_08865)	-	1713162..1713359 (-)	198	WP_011681682.1	helix-turn-helix transcriptional regulator	-
ST4021_RS08845 (ST4021_08870)	-	1713608..1714801 (-)	1194	WP_014608740.1	acetate kinase	-
ST4021_RS08850 (ST4021_08875)	comYH	1714857..1715813 (-)	957	WP_011681684.1	class I SAM-dependent methyltransferase	Machinery gene
ST4021_RS08855 (ST4021_08880)	comGG	1715858..1716175 (-)	318	WP_011681685.1	competence type IV pilus minor pilin ComGG	-
ST4021_RS08860 (ST4021_08885)	comYF	1716153..1716590 (-)	438	WP_011681686.1	competence type IV pilus minor pilin ComGF	Machinery gene
ST4021_RS08865 (ST4021_08890)	comGE	1716574..1716867 (-)	294	WP_011226625.1	competence type IV pilus minor pilin ComGE	-
ST4021_RS08870 (ST4021_08895)	comYD	1716839..1717267 (-)	429	WP_011226626.1	competence type IV pilus minor pilin ComGD	Machinery gene
ST4021_RS08875 (ST4021_08900)	comYC	1717227..1717553 (-)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
ST4021_RS08880 (ST4021_08905)	comYB	1717550..1718650 (-)	1101	WP_120764773.1	competence type IV pilus assembly protein ComGB	Machinery gene
ST4021_RS08885 (ST4021_08910)	comYA	1718532..1719473 (-)	942	WP_014622005.1	competence type IV pilus ATPase ComGA	Machinery gene
ST4021_RS08890 (ST4021_08915)	-	1719554..1719916 (-)	363	WP_023909982.1	DUF1033 family protein	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=510986 ST4021_RS08875 WP_002946126.1 1717227..1717553(-) (comYC) [Streptococcus thermophilus strain 4021]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=510986 ST4021_RS08875 WP_002946126.1 1717227..1717553(-) (comYC) [Streptococcus thermophilus strain 4021]
ATGAAATTGATGTTAAAAAAATTGAATGCCGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTCGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATACAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361