Detailed information NTG0049993

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: KE3_RS00245
• Genome accession: NC_021900
• Coordinates: 49849..50142 (+)
• Length: 97 a.a.
• NCBI ID: WP_020915989.1
• Uniprot ID: A0AB33AJ25
• Organism: Streptococcus lutetiensis 033
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 44849..55142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KE3_RS00230 (KE3_0048)	-	47501..47869 (+)	369	WP_020915986.1	DUF1033 family protein	-
KE3_RS00235 (KE3_0049)	comGA	47941..48882 (+)	942	WP_020915987.1	competence type IV pilus ATPase ComGA	Machinery gene
KE3_RS00240 (KE3_0050)	comGB	48806..49849 (+)	1044	WP_020915988.1	competence type IV pilus assembly protein ComGB	Machinery gene
KE3_RS00245 (KE3_0051)	comGC	49849..50142 (+)	294	WP_020915989.1	competence type IV pilus major pilin ComGC	Machinery gene
KE3_RS00250 (KE3_0052)	comGD	50126..50557 (+)	432	WP_020915990.1	competence type IV pilus minor pilin ComGD	Machinery gene
KE3_RS00255 (KE3_0053)	comGE	50511..50804 (+)	294	WP_020915991.1	competence type IV pilus minor pilin ComGE	Machinery gene
KE3_RS00260 (KE3_0054)	comGF	50788..51225 (+)	438	WP_043894883.1	competence type IV pilus minor pilin ComGF	Machinery gene
KE3_RS00265 (KE3_0055)	comGG	51197..51547 (+)	351	WP_020915993.1	competence type IV pilus minor pilin ComGG	Machinery gene
KE3_RS00270 (KE3_0056)	comGH	51601..52557 (+)	957	WP_020915994.1	class I SAM-dependent methyltransferase	Machinery gene
KE3_RS00275 (KE3_0057)	-	52611..53810 (+)	1200	WP_020915995.1	acetate kinase	-
KE3_RS00280 (KE3_0058)	-	53970..54167 (+)	198	WP_020915996.1	helix-turn-helix transcriptional regulator	-
KE3_RS00285 (KE3_0059)	-	54184..54384 (+)	201	WP_020915997.1	hypothetical protein	-
KE3_RS00290 (KE3_0060)	-	54385..54840 (+)	456	WP_020915998.1	hypothetical protein	-

Sequence

Protein

• Length: 97 a.a.
• Molecular weight: 11018.16 Da
• Isoelectric Point: 10.1006

>NTDB_id=49993 KE3_RS00245 WP_020915989.1 49849..50142(+) (comGC) [Streptococcus lutetiensis 033]
MKNIWKKLRKKSVEAFTLVEMLIVLLIIGVLMLLFVPNLSKQKEVVHEKGDAAVVKVVESQMELYEVKTGKQPTVNDLVK
AEYISKDQAQTYNAAKK

Nucleotide

• Length: 294 bp

>NTDB_id=49993 KE3_RS00245 WP_020915989.1 49849..50142(+) (comGC) [Streptococcus lutetiensis 033]
ATGAAAAACATTTGGAAAAAACTACGTAAAAAGTCTGTAGAAGCTTTTACACTTGTGGAGATGTTGATTGTTTTGCTAAT
CATTGGTGTCTTGATGCTGTTATTTGTGCCAAACTTGAGCAAGCAAAAAGAGGTTGTGCATGAAAAAGGAGATGCTGCTG
TTGTCAAAGTTGTCGAAAGTCAGATGGAGCTTTATGAAGTGAAGACAGGTAAACAACCAACTGTAAATGATTTGGTGAAA
GCTGAATATATTTCAAAAGACCAAGCTCAAACATATAATGCGGCTAAAAAATAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (13-34)

3D structure

• AlphaFold DB: A0AB33AJ25

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus gordonii str. Challis substr. CH1	68.539	91.753	0.629
comGC	Streptococcus suis isolate S10	60.87	94.845	0.577
comGC/cglC	Streptococcus mitis SK321	56.989	95.876	0.546
comGC/cglC	Streptococcus pneumoniae Rx1	56.522	94.845	0.536
comGC/cglC	Streptococcus pneumoniae D39	56.522	94.845	0.536
comGC/cglC	Streptococcus pneumoniae R6	56.522	94.845	0.536
comGC/cglC	Streptococcus pneumoniae TIGR4	56.522	94.845	0.536
comGC/cglC	Streptococcus mitis NCTC 12261	56.522	94.845	0.536
comGC	Streptococcus mutans UA140	56.322	89.691	0.505
comGC	Streptococcus mutans UA159	56.322	89.691	0.505
comGC	Lactococcus lactis subsp. cremoris KW2	51.685	91.753	0.474
comGC	Latilactobacillus sakei subsp. sakei 23K	45.57	81.443	0.371