Detailed information NTG0449992

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: FOC71_RS01855
• Genome accession: NZ_CP053999
• Coordinates: 355405..356154 (-)
• Length: 249 a.a.
• NCBI ID: WP_003075488.1
• Uniprot ID: T1ZH01
• Organism: Streptococcus intermedius strain FDAARGOS_769
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 350405..361154

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC71_RS01835 (FOC71_01835)	-	350809..352431 (+)	1623	WP_003075484.1	ATP-binding cassette domain-containing protein	-
FOC71_RS01840 (FOC71_01840)	-	352505..355081 (+)	2577	WP_003075486.1	YfhO family protein	-
FOC71_RS01855 (FOC71_01855)	comE	355405..356154 (-)	750	WP_003075488.1	competence system response regulator transcription factor ComE	Regulator
FOC71_RS01860 (FOC71_01860)	comD/comD1	356154..357479 (-)	1326	WP_003075490.1	GHKL domain-containing protein	Regulator
FOC71_RS01865 (FOC71_01865)	-	357496..357642 (-)	147	WP_003075491.1	bacteriocin	-
FOC71_RS01875 (FOC71_01875)	rlmH	357919..358398 (-)	480	WP_003075493.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FOC71_RS01880 (FOC71_01880)	htrA	358602..359792 (+)	1191	WP_003075495.1	trypsin-like peptidase domain-containing protein	Regulator
FOC71_RS01885 (FOC71_01885)	spo0J	359847..360614 (+)	768	WP_003075496.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29207.78 Da
• Isoelectric Point: 8.0443

>NTDB_id=449992 FOC71_RS01855 WP_003075488.1 355405..356154(-) (comE) [Streptococcus intermedius strain FDAARGOS_769]
MKVLVLEDEISHQVRMETTLAEIAKEMGISIKVKVTGKIREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETQRFFSPHKSYLVNIGNIKSYDKKMKEIIFYEDHRCPITRMKIGKL
KTILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=449992 FOC71_RS01855 WP_003075488.1 355405..356154(-) (comE) [Streptococcus intermedius strain FDAARGOS_769]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAGAT
GGGAATTTCTATCAAAGTTAAAGTAACTGGAAAAATAAGAGAATTTAAAGAATATATTGAGAATGATGAAGTAAATCAAT
TATACTTTTTAGATATTGATATTAAAGGGGAAGAGACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCATAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACTATGACTTTTAAATATAAAGTTTCTGCACTAGATTT
TGTTGATAAAAATTTGAATGATGTTGCTTTTAAAAAACATATAAAAGATAGCATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTTCGTGGTGGAGAAGTTAGAATGCCATTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTAGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGACAAGGAGACACAGCGTTTCTTTTCACCTCATAAATCTTATTTAGTTAATATTGGAAATATTAAGA
GTTATGACAAAAAAATGAAAGAAATTATTTTTTATGAAGATCACCGTTGCCCGATTACTCGAATGAAAATTGGAAAGTTG
AAAACTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: T1ZH01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	71.311	97.992	0.699
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	71.311	97.992	0.699
comE	Streptococcus infantis strain Atu-4	70.612	98.394	0.695
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.161	100	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361