Detailed information NTG0042046

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPPN_RS11285
• Genome accession: NC_015875
• Coordinates: 2185361..2186113 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pseudopneumoniae IS7493
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2180361..2191113

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPPN_RS11265 (SPPN_11355)	-	2181806..2184448 (-)	2643	WP_000472063.1	YhgE/Pip domain-containing protein	-
SPPN_RS11270 (SPPN_11360)	-	2184576..2185118 (+)	543	WP_001158278.1	TetR/AcrR family transcriptional regulator	-
SPPN_RS11285 (SPPN_11365)	comE	2185361..2186113 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPPN_RS11290 (SPPN_11370)	comD/comD2	2186110..2187435 (-)	1326	WP_001048117.1	competence system sensor histidine kinase ComD	Regulator
SPPN_RS11295 (SPPN_11375)	comC/comC1	2187456..2187581 (-)	126	WP_000799687.1	competence-stimulating peptide ComC	Regulator
SPPN_RS11305 (SPPN_11380)	rlmH	2187860..2188339 (-)	480	WP_000695932.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPPN_RS11310 (SPPN_11385)	htrA	2188522..2189703 (+)	1182	WP_000681604.1	S1C family serine protease	Regulator
SPPN_RS11315 (SPPN_11390)	spo0J	2189761..2190519 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=42046 SPPN_RS11285 WP_000866065.1 2185361..2186113(-) (comE) [Streptococcus pseudopneumoniae IS7493]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=42046 SPPN_RS11285 WP_000866065.1 2185361..2186113(-) (comE) [Streptococcus pseudopneumoniae IS7493]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGATGAAGTAAATCAGC
TTTATTTCCTAGATATTGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTTTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTGGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATCCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTACGTATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACTATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATTAGAG
AGATTGATCGAAAAAATCTAGAAATTGTTTTCTATGAAGATCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAGAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408