Detailed information NTG0042049

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPPN_RS11310
• Genome accession: NC_015875
• Coordinates: 2188522..2189703 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681604.1
• Uniprot ID: A0AAW4C7S4
• Organism: Streptococcus pseudopneumoniae IS7493
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2183522..2194703

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPPN_RS11270 (SPPN_11360)	-	2184576..2185118 (+)	543	WP_001158278.1	TetR/AcrR family transcriptional regulator	-
SPPN_RS11285 (SPPN_11365)	comE	2185361..2186113 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPPN_RS11290 (SPPN_11370)	comD/comD2	2186110..2187435 (-)	1326	WP_001048117.1	competence system sensor histidine kinase ComD	Regulator
SPPN_RS11295 (SPPN_11375)	comC/comC1	2187456..2187581 (-)	126	WP_000799687.1	competence-stimulating peptide ComC	Regulator
SPPN_RS11305 (SPPN_11380)	rlmH	2187860..2188339 (-)	480	WP_000695932.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPPN_RS11310 (SPPN_11385)	htrA	2188522..2189703 (+)	1182	WP_000681604.1	S1C family serine protease	Regulator
SPPN_RS11315 (SPPN_11390)	spo0J	2189761..2190519 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41828.67 Da
• Isoelectric Point: 6.1498

>NTDB_id=42049 SPPN_RS11310 WP_000681604.1 2188522..2189703(+) (htrA) [Streptococcus pseudopneumoniae IS7493]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDETDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSIQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=42049 SPPN_RS11310 WP_000681604.1 2188522..2189703(+) (htrA) [Streptococcus pseudopneumoniae IS7493]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAATAAAGTAAAAGATGCCGTTGTATCCGTTATTACTTATTCAGCA
AATAGACAAAATAGCGTATTTGGCAATGATGAGACTGATACAGATTCTCAGCAAATCTCTAGTGAGGGATCTGGCGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCTAGCAAAGTAGATATTCGAT
TATCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCGGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGTCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAATCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATCCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGATACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATCACTTACTATCGCA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	98.728	100	0.987
htrA	Streptococcus pneumoniae D39	98.728	100	0.987
htrA	Streptococcus pneumoniae R6	98.728	100	0.987
htrA	Streptococcus pneumoniae TIGR4	98.728	100	0.987
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.674
htrA	Streptococcus mutans UA159	54.822	100	0.55