Detailed information NTG0418289

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: M594_RS09990
• Genome accession: NZ_CP047883
• Coordinates: 2081583..2082335 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866074.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2076583..2087335

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS09970 (M594_10015)	-	2078028..2080670 (-)	2643	WP_173876759.1	YhgE/Pip domain-containing protein	-
M594_RS09975 (M594_10020)	-	2080798..2081340 (+)	543	WP_173876721.1	TetR/AcrR family transcriptional regulator	-
M594_RS09990 (M594_10035)	comE	2081583..2082335 (-)	753	WP_000866074.1	competence system response regulator transcription factor ComE	Regulator
M594_RS09995 (M594_10040)	comD/comD2	2082332..2083657 (-)	1326	WP_173876722.1	competence system sensor histidine kinase ComD	Regulator
M594_RS10000 (M594_10045)	comC/comC2	2083678..2083803 (-)	126	WP_049535516.1	competence-stimulating peptide ComC	Regulator
M594_RS10010 (M594_10055)	rlmH	2084086..2084565 (-)	480	WP_042900048.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
M594_RS10015 (M594_10060)	htrA	2084749..2085930 (+)	1182	WP_173876723.1	S1C family serine protease	Regulator
M594_RS10020 (M594_10065)	spo0J	2085988..2086746 (+)	759	WP_173876724.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29939.34 Da
• Isoelectric Point: 6.9221

>NTDB_id=418289 M594_RS09990 WP_000866074.1 2081583..2082335(-) (comE) [Streptococcus mitis strain S022-V3-A4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=418289 M594_RS09990 WP_000866074.1 2081583..2082335(-) (comE) [Streptococcus mitis strain S022-V3-A4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAGTTCAAGGAATATATTGAAAACGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCAACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTCGATAAGGATATTAATGATGAGTTATTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTACAATTATAAGGGAAATGATTTAAAAATTCCTTATCATGACATTCTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCCAAAGAATTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGAGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATAGAAAGAATTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis SK321	100	100	1
comE	Streptococcus pneumoniae Rx1	99.2	100	0.992
comE	Streptococcus pneumoniae D39	99.2	100	0.992
comE	Streptococcus pneumoniae R6	99.2	100	0.992
comE	Streptococcus pneumoniae TIGR4	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	99.2	100	0.992
comE	Streptococcus infantis strain Atu-4	92	100	0.92
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408