Detailed information NTG0418292

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: M594_RS10015
• Genome accession: NZ_CP047883
• Coordinates: 2084749..2085930 (+)
• Length: 393 a.a.
• NCBI ID: WP_173876723.1
• Uniprot ID: A0A6M9F2N5
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2079749..2090930

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS09975 (M594_10020)	-	2080798..2081340 (+)	543	WP_173876721.1	TetR/AcrR family transcriptional regulator	-
M594_RS09990 (M594_10035)	comE	2081583..2082335 (-)	753	WP_000866074.1	competence system response regulator transcription factor ComE	Regulator
M594_RS09995 (M594_10040)	comD/comD2	2082332..2083657 (-)	1326	WP_173876722.1	competence system sensor histidine kinase ComD	Regulator
M594_RS10000 (M594_10045)	comC/comC2	2083678..2083803 (-)	126	WP_049535516.1	competence-stimulating peptide ComC	Regulator
M594_RS10010 (M594_10055)	rlmH	2084086..2084565 (-)	480	WP_042900048.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
M594_RS10015 (M594_10060)	htrA	2084749..2085930 (+)	1182	WP_173876723.1	S1C family serine protease	Regulator
M594_RS10020 (M594_10065)	spo0J	2085988..2086746 (+)	759	WP_173876724.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41753.56 Da
• Isoelectric Point: 6.1475

>NTDB_id=418292 M594_RS10015 WP_173876723.1 2084749..2085930(+) (htrA) [Streptococcus mitis strain S022-V3-A4]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSINQLTQKSGVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQGNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=418292 M594_RS10015 WP_173876723.1 2084749..2085930(+) (htrA) [Streptococcus mitis strain S022-V3-A4]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGGGCTTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTGGTGTAAGCAACTCTAACAACAATAGCACCATTACACAGACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAACAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTATATTGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
ATTAGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAGACGGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATTCAAGGACAGGTTATAGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTTACATCTGGTGTAGTT
GTTCGTTCTGTGCAGGGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A6M9F2N5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.473	100	0.985
htrA	Streptococcus pneumoniae Rx1	97.455	100	0.975
htrA	Streptococcus pneumoniae D39	97.455	100	0.975
htrA	Streptococcus pneumoniae R6	97.455	100	0.975
htrA	Streptococcus pneumoniae TIGR4	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.162	100	0.667
htrA	Streptococcus mutans UA159	54.569	100	0.547