Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   M594_RS10000 Genome accession   NZ_CP047883
Coordinates   2083678..2083803 (-) Length   41 a.a.
NCBI ID   WP_049535516.1    Uniprot ID   A0A501VYB5
Organism   Streptococcus mitis strain S022-V3-A4     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2078678..2088803
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS09975 (M594_10020) - 2080798..2081340 (+) 543 WP_173876721.1 TetR/AcrR family transcriptional regulator -
  M594_RS09990 (M594_10035) comE 2081583..2082335 (-) 753 WP_000866074.1 competence system response regulator transcription factor ComE Regulator
  M594_RS09995 (M594_10040) comD/comD2 2082332..2083657 (-) 1326 WP_173876722.1 competence system sensor histidine kinase ComD Regulator
  M594_RS10000 (M594_10045) comC/comC2 2083678..2083803 (-) 126 WP_049535516.1 competence-stimulating peptide ComC Regulator
  M594_RS10010 (M594_10055) rlmH 2084086..2084565 (-) 480 WP_042900048.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M594_RS10015 (M594_10060) htrA 2084749..2085930 (+) 1182 WP_173876723.1 S1C family serine protease Regulator
  M594_RS10020 (M594_10065) spo0J 2085988..2086746 (+) 759 WP_173876724.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4850.79 Da        Isoelectric Point: 10.7877

>NTDB_id=418291 M594_RS10000 WP_049535516.1 2083678..2083803(-) (comC/comC2) [Streptococcus mitis strain S022-V3-A4]
MKNTVKLEQFVALKEKDLQKIKGGESRVSDILLDFLFRRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=418291 M594_RS10000 WP_049535516.1 2083678..2083803(-) (comC/comC2) [Streptococcus mitis strain S022-V3-A4]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCCTTGAAGGAAAAAGACTTGCAAAAGATTAAAGGTGGGGAAAGTAG
GGTTTCAGACATCCTCCTTGATTTTCTTTTCCGACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A501VYB5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

87.805

100

0.878
  comC/comC2 Streptococcus pneumoniae TIGR4

87.805

100

0.878
  comC Streptococcus mitis SK321

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78
  comC Streptococcus mitis NCTC 12261

60

97.561

0.585

Multiple sequence alignment