Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   M594_RS09995 Genome accession   NZ_CP047883
Coordinates   2082332..2083657 (-) Length   441 a.a.
NCBI ID   WP_173876722.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V3-A4     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2077332..2088657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS09970 (M594_10015) - 2078028..2080670 (-) 2643 WP_173876759.1 YhgE/Pip domain-containing protein -
  M594_RS09975 (M594_10020) - 2080798..2081340 (+) 543 WP_173876721.1 TetR/AcrR family transcriptional regulator -
  M594_RS09990 (M594_10035) comE 2081583..2082335 (-) 753 WP_000866074.1 competence system response regulator transcription factor ComE Regulator
  M594_RS09995 (M594_10040) comD/comD2 2082332..2083657 (-) 1326 WP_173876722.1 competence system sensor histidine kinase ComD Regulator
  M594_RS10000 (M594_10045) comC/comC2 2083678..2083803 (-) 126 WP_049535516.1 competence-stimulating peptide ComC Regulator
  M594_RS10010 (M594_10055) rlmH 2084086..2084565 (-) 480 WP_042900048.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M594_RS10015 (M594_10060) htrA 2084749..2085930 (+) 1182 WP_173876723.1 S1C family serine protease Regulator
  M594_RS10020 (M594_10065) spo0J 2085988..2086746 (+) 759 WP_173876724.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 50925.34 Da        Isoelectric Point: 7.1108

>NTDB_id=418290 M594_RS09995 WP_173876722.1 2082332..2083657(-) (comD/comD2) [Streptococcus mitis strain S022-V3-A4]
MNLLGFGTVIVHFLIISHSYRLICKGQIKAKELYVFGAYTLLVEAVLELTFYFLSLDGLGIVTFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESAHNFLSVTFSSITGDNFVLQYYYPFFSVVTVLTYFVVSKIIHYFHLELTYFDKDYLYPFLKK
VFIALLLLHVASFVSDIVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKDQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDIITRLPIDLLDLVRIMSVLLNNAVEGSADSYKKHMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSIFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=418290 M594_RS09995 WP_173876722.1 2082332..2083657(-) (comD/comD2) [Streptococcus mitis strain S022-V3-A4]
ATGAATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCA
AATAAAAGCAAAGGAACTATACGTTTTTGGTGCTTATACATTACTAGTGGAAGCAGTACTTGAACTTACCTTCTATTTTC
TATCTTTAGATGGGTTAGGAATTGTAACATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGACTATTTCTAAGTTTACTACTATCTCTTTTATATGAGAGCGCTCATAATTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGACAATTTTGTTTTACAATATTATTACCCATTCTTTTCCGTTGTAACGGTGTTGACCTATTTTG
TTGTCTCAAAAATCATTCATTATTTCCACTTAGAACTAACCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTATTGCTTTACTACTGCTACATGTTGCATCTTTCGTTTCAGATATAGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTATCATCTATTGTCTTTATTTCTCTCCTTTTGACCTTTTTTGCAATGAATTCACATAAAGATCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAAAACTACACAGATGAAATTGTCGGTCTATAT
AATGAAATCCGTGGCTTTCGACATGATTATGCTGGTATGCTTGTTAGTATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCCAATCACAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TAAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATATAATTACTAGACTACCAATAGACCTTCTGGATTTGGTTCGTATTATGAGTGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGTTATAAAAAACATATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCTACTAAGGGAAGA
AATCGTGGGGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAATAACATTATTTTAGAAACAGAGATGGAAGG
CAGTATATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(335-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

92.063

100

0.921
  comD Streptococcus mitis SK321

91.61

100

0.916
  comD/comD1 Streptococcus pneumoniae D39

91.156

100

0.912
  comD/comD1 Streptococcus pneumoniae R6

91.156

100

0.912
  comD/comD1 Streptococcus pneumoniae Rx1

91.156

100

0.912
  comD Streptococcus mitis NCTC 12261

85.488

100

0.855
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.549

85.941

0.417
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

48.936

85.261

0.417

Multiple sequence alignment