Detailed information NTG0409403

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: GPZ88_RS03285
• Genome accession: NZ_CP046919
• Coordinates: 636800..637534 (-)
• Length: 244 a.a.
• NCBI ID: WP_052071091.1
• Uniprot ID: A0A091BRI3
• Organism: Streptococcus ruminicola strain CNU_G2
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 631800..642534

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPZ88_RS03255 (GPZ88_03230)	-	632111..633049 (-)	939	WP_166043380.1	3'-5' exoribonuclease YhaM family protein	-
GPZ88_RS03260 (GPZ88_03235)	rmuC	633039..634313 (-)	1275	WP_006531897.1	DNA recombination protein RmuC	-
GPZ88_RS03265 (GPZ88_03240)	-	634315..634947 (-)	633	WP_166043382.1	thiamine diphosphokinase	-
GPZ88_RS03270 (GPZ88_03245)	rpe	634940..635602 (-)	663	WP_006531895.1	ribulose-phosphate 3-epimerase	-
GPZ88_RS03275 (GPZ88_03250)	rsgA	635609..636481 (-)	873	WP_006531894.1	ribosome small subunit-dependent GTPase A	-
GPZ88_RS03285 (GPZ88_03260)	comE/comE2	636800..637534 (-)	735	WP_052071091.1	LytR/AlgR family response regulator transcription factor	Regulator
GPZ88_RS03290 (GPZ88_03265)	comD/comD3	638195..639571 (-)	1377	WP_240915106.1	sensor histidine kinase	Regulator
GPZ88_RS03295 (GPZ88_03270)	comD/comD3	639568..640650 (-)	1083	WP_240915107.1	sensor histidine kinase	Regulator
GPZ88_RS10350	comD/comD2	640943..641773 (-)	831	WP_240915108.1	sensor histidine kinase	Regulator

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28825.11 Da
• Isoelectric Point: 6.4989

>NTDB_id=409403 GPZ88_RS03285 WP_052071091.1 636800..637534(-) (comE/comE2) [Streptococcus ruminicola strain CNU_G2]
MIDIYVLEDNVNQQFRIEKMIGDLLETNQWETRHFDLFSEPDCLTNLVEESFPQIFFLDIDIHGDNTKGIEVAKAIREKS
RTATIVFVTTHSEFMLLTYRAQVSALDFIDKTDKDDAIKDNLKKCLQKVFEDQGFNIPKEIFVFENNKTKIRIPLEDILY
FETAESHRLKLITKTGQRHFYGSIKEVMQANQKLFRCHKSYLINLNNIVRLDKKEGLVYFDDDKACYVSRKYIKDLRSKM
ENLK

Nucleotide

• Length: 735 bp

>NTDB_id=409403 GPZ88_RS03285 WP_052071091.1 636800..637534(-) (comE/comE2) [Streptococcus ruminicola strain CNU_G2]
ATGATTGATATCTATGTATTAGAAGATAATGTAAATCAGCAGTTCCGTATTGAAAAAATGATTGGAGATTTACTCGAGAC
AAATCAGTGGGAAACTCGTCATTTTGATTTATTTAGTGAACCTGATTGTTTAACTAACCTAGTTGAGGAGTCTTTTCCTC
AAATTTTTTTCCTGGATATTGATATTCATGGAGATAATACCAAAGGAATTGAAGTGGCTAAGGCGATAAGGGAAAAATCA
CGCACAGCGACAATTGTTTTTGTGACGACTCACTCTGAATTCATGTTATTAACTTATCGAGCGCAAGTTAGTGCACTTGA
TTTTATTGATAAAACAGATAAAGATGATGCGATAAAAGATAACTTAAAAAAATGCTTGCAAAAGGTCTTTGAGGACCAAG
GTTTTAACATTCCTAAGGAAATATTTGTTTTTGAAAATAACAAAACGAAAATCCGCATTCCCTTGGAAGATATCCTTTAT
TTTGAAACCGCAGAAAGTCATCGCCTGAAGTTGATTACAAAAACTGGGCAACGTCACTTTTATGGTTCAATCAAAGAAGT
GATGCAAGCTAATCAGAAATTATTTAGATGTCATAAATCATATCTGATTAACTTAAATAATATTGTTAGGTTAGATAAAA
AAGAAGGTTTGGTTTATTTTGACGATGATAAAGCCTGTTATGTTTCTAGAAAATATATCAAAGACTTAAGGTCAAAAATG
GAAAATCTGAAATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (19-120)

• LytTr DNA-binding domain (LytTR) (151-240)

3D structure

• AlphaFold DB: A0A091BRI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	100	100	1
comE/comE1	Streptococcus equinus JB1	45.041	99.18	0.447
comE/blpR	Streptococcus mutans UA159	40.664	98.77	0.402
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.255	100	0.373
comE/comE2	Streptococcus gordonii strain NCTC7865	36.255	100	0.373
comE	Streptococcus pneumoniae R6	35.039	100	0.365
comE	Streptococcus pneumoniae TIGR4	35.039	100	0.365
comE	Streptococcus mitis SK321	35.039	100	0.365
comE	Streptococcus mitis NCTC 12261	35.039	100	0.365
comE	Streptococcus pneumoniae Rx1	35.039	100	0.365
comE	Streptococcus pneumoniae D39	35.039	100	0.365