Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   GO995_RS08470 Genome accession   NZ_CP046624
Coordinates   1698932..1699666 (-) Length   244 a.a.
NCBI ID   WP_052071091.1    Uniprot ID   A0A091BRI3
Organism   Streptococcus ruminicola strain CNU_G3     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1693932..1704666
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GO995_RS08435 (GO995_08435) - 1693958..1694143 (+) 186 WP_238385868.1 hypothetical protein -
  GO995_RS08440 (GO995_08440) - 1694244..1695182 (-) 939 WP_157629393.1 3'-5' exoribonuclease YhaM family protein -
  GO995_RS08445 (GO995_08445) rmuC 1695172..1696446 (-) 1275 WP_006531897.1 DNA recombination protein RmuC -
  GO995_RS08450 (GO995_08450) - 1696448..1697080 (-) 633 WP_157629394.1 thiamine diphosphokinase -
  GO995_RS08455 (GO995_08455) rpe 1697073..1697735 (-) 663 WP_074560922.1 ribulose-phosphate 3-epimerase -
  GO995_RS08460 (GO995_08460) rsgA 1697742..1698614 (-) 873 WP_006531894.1 ribosome small subunit-dependent GTPase A -
  GO995_RS08470 (GO995_08470) comE/comE2 1698932..1699666 (-) 735 WP_052071091.1 LytR/AlgR family response regulator transcription factor Regulator
  GO995_RS08475 (GO995_08475) comD/comD3 1700327..1701709 (-) 1383 WP_157629395.1 sensor histidine kinase Regulator
  GO995_RS08480 (GO995_08480) comD/comD2 1701722..1702654 (-) 933 WP_238385869.1 sensor histidine kinase Regulator
  GO995_RS08485 (GO995_08485) - 1703447..1703740 (-) 294 WP_157629397.1 bacteriocin immunity protein -
  GO995_RS08490 (GO995_08490) - 1703768..1704073 (-) 306 WP_157629398.1 bacteriocin immunity protein -
  GO995_RS08495 (GO995_08495) - 1704086..1704235 (-) 150 WP_093815783.1 bacteriocin -
  GO995_RS08500 (GO995_08500) comC/comC1 1704497..1704649 (+) 153 WP_157327338.1 hypothetical protein Regulator

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28825.11 Da        Isoelectric Point: 6.4989

>NTDB_id=406186 GO995_RS08470 WP_052071091.1 1698932..1699666(-) (comE/comE2) [Streptococcus ruminicola strain CNU_G3]
MIDIYVLEDNVNQQFRIEKMIGDLLETNQWETRHFDLFSEPDCLTNLVEESFPQIFFLDIDIHGDNTKGIEVAKAIREKS
RTATIVFVTTHSEFMLLTYRAQVSALDFIDKTDKDDAIKDNLKKCLQKVFEDQGFNIPKEIFVFENNKTKIRIPLEDILY
FETAESHRLKLITKTGQRHFYGSIKEVMQANQKLFRCHKSYLINLNNIVRLDKKEGLVYFDDDKACYVSRKYIKDLRSKM
ENLK

Nucleotide


Download         Length: 735 bp        

>NTDB_id=406186 GO995_RS08470 WP_052071091.1 1698932..1699666(-) (comE/comE2) [Streptococcus ruminicola strain CNU_G3]
ATGATTGATATCTATGTATTAGAAGATAATGTAAATCAGCAGTTCCGTATTGAAAAAATGATTGGAGATTTACTCGAGAC
AAATCAGTGGGAAACTCGTCATTTTGATTTATTTAGTGAACCTGATTGTTTAACTAACCTAGTTGAGGAGTCTTTTCCTC
AAATTTTTTTCCTGGATATTGATATTCATGGAGATAATACCAAAGGAATTGAAGTGGCTAAGGCGATAAGGGAAAAATCA
CGCACAGCGACAATTGTTTTTGTGACGACTCACTCTGAATTCATGTTATTAACTTATCGAGCGCAAGTTAGTGCACTTGA
TTTTATTGATAAAACAGATAAAGATGATGCGATAAAAGATAACTTAAAAAAATGCTTGCAAAAGGTCTTTGAGGACCAAG
GTTTTAACATTCCTAAGGAAATATTTGTTTTTGAAAATAACAAAACGAAAATCCGCATTCCCTTGGAAGATATCCTTTAT
TTTGAAACCGCGGAAAGTCATCGCCTGAAGTTGATTACAAAAACTGGGCAACGTCATTTTTATGGTTCAATCAAAGAAGT
GATGCAAGCTAATCAGAAATTATTTAGATGTCATAAATCATATCTGATTAACCTAAATAATATTGTTAGGTTAGATAAAA
AAGAAGGTTTGGTTTATTTTGACGATGATAAAGCCTGTTATGTTTCTAGAAAATATATCAAAGACTTAAGGTCAAAAATG
GAAAATCTGAAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(19-120)

LytTr DNA-binding domain (LytTR)

(151-240)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A091BRI3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE2 Streptococcus equinus JB1

100

100

1
  comE/comE1 Streptococcus equinus JB1

45.041

99.18

0.447
  comE/blpR Streptococcus mutans UA159

40.664

98.77

0.402
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

36.255

100

0.373
  comE/comE2 Streptococcus gordonii strain NCTC7865

36.255

100

0.373
  comE Streptococcus pneumoniae R6

35.039

100

0.365
  comE Streptococcus pneumoniae TIGR4

35.039

100

0.365
  comE Streptococcus mitis SK321

35.039

100

0.365
  comE Streptococcus mitis NCTC 12261

35.039

100

0.365
  comE Streptococcus pneumoniae Rx1

35.039

100

0.365
  comE Streptococcus pneumoniae D39

35.039

100

0.365

Multiple sequence alignment