Detailed information NTG0040229

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SOR_RS09680
• Genome accession: NC_015291
• Coordinates: 1953311..1954057 (-)
• Length: 248 a.a.
• NCBI ID: WP_000866078.1
• Uniprot ID: F2QG60
• Organism: Streptococcus oralis Uo5
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1948311..1959057

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SOR_RS09660 (SOR_1980)	-	1949743..1952397 (-)	2655	WP_000472071.1	YhgE/Pip domain-containing protein	-
SOR_RS09665 (SOR_1981)	-	1952526..1953068 (+)	543	WP_000665079.1	TetR/AcrR family transcriptional regulator	-
SOR_RS09680 (SOR_1984)	comE	1953311..1954057 (-)	747	WP_000866078.1	competence system response regulator transcription factor ComE	Regulator
SOR_RS09685 (SOR_1985)	comD	1954054..1955373 (-)	1320	WP_000362884.1	competence system sensor histidine kinase ComD	Regulator
SOR_RS09690 (SOR_1986)	comC/comC2	1955394..1955519 (-)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
SOR_RS09700 (SOR_1989)	rlmH	1955801..1956280 (-)	480	WP_000694219.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SOR_RS09705 (SOR_1990)	htrA	1956466..1957662 (+)	1197	WP_000681803.1	S1C family serine protease	Regulator
SOR_RS09710 (SOR_1991)	spo0J	1957720..1958478 (+)	759	WP_000410359.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 29655.85 Da
• Isoelectric Point: 6.2411

>NTDB_id=40229 SOR_RS09680 WP_000866078.1 1953311..1954057(-) (comE) [Streptococcus oralis Uo5]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEEKN

Nucleotide

• Length: 747 bp

>NTDB_id=40229 SOR_RS09680 WP_000866078.1 1953311..1954057(-) (comE) [Streptococcus oralis Uo5]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGACATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAATGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCAAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAACTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAAGAAAAAAACTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: F2QG60

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.161	100	0.952
comE	Streptococcus mitis SK321	94.355	100	0.944
comE	Streptococcus pneumoniae Rx1	93.548	100	0.935
comE	Streptococcus pneumoniae D39	93.548	100	0.935
comE	Streptococcus pneumoniae R6	93.548	100	0.935
comE	Streptococcus pneumoniae TIGR4	93.548	100	0.935
comE	Streptococcus infantis strain Atu-4	92.742	100	0.927
comE/comE2	Streptococcus gordonii strain NCTC7865	62.5	100	0.625
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.5	100	0.625
comE/blpR	Streptococcus mutans UA159	40	100	0.403