Detailed information NTG0390391

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FSA40_RS08885
• Genome accession: NZ_CP044493
• Coordinates: 1751293..1752045 (-)
• Length: 250 a.a.
• NCBI ID: WP_151416433.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain MD
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1746293..1757045

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FSA40_RS08850 (FSA40_1772)	-	1746309..1746713 (-)	405	WP_002263912.1	hypothetical protein	-
FSA40_RS08855 (FSA40_1773)	-	1746860..1747279 (-)	420	WP_151416432.1	hypothetical protein	-
FSA40_RS08865 (FSA40_1775)	-	1748660..1749061 (-)	402	WP_002310604.1	hypothetical protein	-
FSA40_RS08870 (FSA40_1776)	cipB	1749192..1749422 (-)	231	WP_002265368.1	Blp family class II bacteriocin	Regulator
FSA40_RS08875 (FSA40_1777)	comC/blpC	1749689..1749829 (+)	141	WP_002270250.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
FSA40_RS08880 (FSA40_1778)	comD/blpH	1749971..1751296 (-)	1326	WP_002292008.1	GHKL domain-containing protein	Regulator
FSA40_RS08885 (FSA40_1779)	comE/blpR	1751293..1752045 (-)	753	WP_151416433.1	response regulator transcription factor	Regulator
FSA40_RS08890 (FSA40_1780)	-	1752517..1753155 (-)	639	WP_002265117.1	VTT domain-containing protein	-
FSA40_RS08895 (FSA40_1781)	-	1753202..1753828 (-)	627	WP_002265453.1	hypothetical protein	-
FSA40_RS08900 (FSA40_1782)	der	1753903..1755213 (-)	1311	WP_063330949.1	ribosome biogenesis GTPase Der	-
FSA40_RS08905 (FSA40_1783)	dnaI	1755226..1756125 (-)	900	WP_002265120.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29405.82 Da
• Isoelectric Point: 8.2551

>NTDB_id=390391 FSA40_RS08885 WP_151416433.1 1751293..1752045(-) (comE/blpR) [Streptococcus mutans strain MD]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDTIPEKGSHQIFFLDIEIKKEEKKGMEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=390391 FSA40_RS08885 WP_151416433.1 1751293..1752045(-) (comE/blpR) [Streptococcus mutans strain MD]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGATACTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGAATGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGTTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (153-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	98.4	100	0.984
comE/comE1	Streptococcus equinus JB1	46.473	96.4	0.448
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.143	98	0.364
comE/comE2	Streptococcus gordonii strain NCTC7865	37.143	98	0.364