Detailed information NTG0390319

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FSA31_RS08650
• Genome accession: NZ_CP044492
• Coordinates: 1727914..1728666 (-)
• Length: 250 a.a.
• NCBI ID: WP_002284745.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain T8
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1722914..1733666

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FSA31_RS08615 (FSA31_1706)	-	1723540..1723683 (-)	144	WP_002263740.1	hypothetical protein	-
FSA31_RS08625 (FSA31_1707)	-	1723975..1724997 (-)	1023	WP_002284748.1	thioredoxin family protein	-
FSA31_RS08630 (FSA31_1708)	-	1725478..1725666 (-)	189	WP_002284747.1	Blp family class II bacteriocin	-
FSA31_RS08635 (FSA31_1709)	-	1725834..1726043 (-)	210	WP_002268232.1	Blp family class II bacteriocin	-
FSA31_RS08640 (FSA31_1710)	comC/blpC	1726310..1726450 (+)	141	WP_002270250.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
FSA31_RS08645 (FSA31_1711)	comD/blpH	1726592..1727917 (-)	1326	WP_002284746.1	GHKL domain-containing protein	Regulator
FSA31_RS08650 (FSA31_1712)	comE/blpR	1727914..1728666 (-)	753	WP_002284745.1	response regulator transcription factor	Regulator
FSA31_RS08655 (FSA31_1713)	-	1729131..1729769 (-)	639	WP_002262115.1	VTT domain-containing protein	-
FSA31_RS08660 (FSA31_1714)	-	1729817..1730443 (-)	627	WP_002268642.1	hypothetical protein	-
FSA31_RS08665 (FSA31_1715)	der	1730518..1731828 (-)	1311	WP_002262117.1	ribosome biogenesis GTPase Der	-
FSA31_RS08670 (FSA31_1716)	dnaI	1731841..1732740 (-)	900	WP_002284744.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29335.67 Da
• Isoelectric Point: 8.2551

>NTDB_id=390319 FSA31_RS08650 WP_002284745.1 1727914..1728666(-) (comE/blpR) [Streptococcus mutans strain T8]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKTQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=390319 FSA31_RS08650 WP_002284745.1 1727914..1728666(-) (comE/blpR) [Streptococcus mutans strain T8]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAGCAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAAACACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTTTATGGTAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAGCGATTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (153-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	99.2	100	0.992
comE/comE1	Streptococcus equinus JB1	46.473	96.4	0.448
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.249	96.4	0.388
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.551	98	0.368
comE/comE2	Streptococcus gordonii strain NCTC7865	37.551	98	0.368