Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SMUNN2025_RS01280 Genome accession   NC_013928
Coordinates   262505..263257 (+) Length   250 a.a.
NCBI ID   WP_012997565.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 257505..268257
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS01260 (SmuNN2025_0230) dnaI 258431..259330 (+) 900 WP_002265120.1 primosomal protein DnaI -
  SMUNN2025_RS01265 (SmuNN2025_0231) der 259343..260653 (+) 1311 WP_002277684.1 ribosome biogenesis GTPase Der -
  SMUNN2025_RS01270 (SmuNN2025_0232) - 260728..261354 (+) 627 WP_002277685.1 hypothetical protein -
  SMUNN2025_RS01275 (SmuNN2025_0233) - 261402..262040 (+) 639 WP_002262115.1 VTT domain-containing protein -
  SMUNN2025_RS01280 (SmuNN2025_0234) comE/blpR 262505..263257 (+) 753 WP_012997565.1 response regulator transcription factor Regulator
  SMUNN2025_RS01285 (SmuNN2025_0235) comD/blpH 263254..264579 (+) 1326 WP_041160308.1 sensor histidine kinase Regulator
  SMUNN2025_RS01290 (SmuNN2025_0236) comC/blpC 264721..264861 (-) 141 WP_012997567.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  SMUNN2025_RS01295 (SmuNN2025_0237) cipB 265128..265358 (+) 231 WP_012997568.1 Blp family class II bacteriocin Regulator
  SMUNN2025_RS01300 (SmuNN2025_0238) - 265489..265890 (+) 402 WP_002310604.1 hypothetical protein -
  SMUNN2025_RS01305 (SmuNN2025_0240) - 267270..267689 (+) 420 WP_002263913.1 hypothetical protein -
  SMUNN2025_RS01310 (SmuNN2025_0241) - 267836..268240 (+) 405 WP_002263912.1 hypothetical protein -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29387.79 Da        Isoelectric Point: 8.2551

>NTDB_id=36569 SMUNN2025_RS01280 WP_012997565.1 262505..263257(+) (comE/blpR) [Streptococcus mutans NN2025]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDTIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIELALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=36569 SMUNN2025_RS01280 WP_012997565.1 262505..263257(+) (comE/blpR) [Streptococcus mutans NN2025]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGATACTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATTAGCGCTGTATTATGCTATGGAAAACA
GTCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(153-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

98.8

100

0.988
  comE/comE1 Streptococcus equinus JB1

46.888

96.4

0.452
  comE Streptococcus mitis NCTC 12261

41.7

98.8

0.412
  comE Streptococcus infantis strain Atu-4

41.7

98.8

0.412
  comE Streptococcus pneumoniae Rx1

41.296

98.8

0.408
  comE Streptococcus mitis SK321

41.296

98.8

0.408
  comE Streptococcus pneumoniae D39

41.296

98.8

0.408
  comE Streptococcus pneumoniae R6

41.296

98.8

0.408
  comE Streptococcus pneumoniae TIGR4

41.296

98.8

0.408
  comE/comE2 Streptococcus equinus JB1

40.664

96.4

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368

Multiple sequence alignment