Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/blpH   Type   Regulator
Locus tag   SMUNN2025_RS01285 Genome accession   NC_013928
Coordinates   263254..264579 (+) Length   441 a.a.
NCBI ID   WP_041160308.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   phosphorylation of ComE; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 258254..269579
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS01260 (SmuNN2025_0230) dnaI 258431..259330 (+) 900 WP_002265120.1 primosomal protein DnaI -
  SMUNN2025_RS01265 (SmuNN2025_0231) der 259343..260653 (+) 1311 WP_002277684.1 ribosome biogenesis GTPase Der -
  SMUNN2025_RS01270 (SmuNN2025_0232) - 260728..261354 (+) 627 WP_002277685.1 hypothetical protein -
  SMUNN2025_RS01275 (SmuNN2025_0233) - 261402..262040 (+) 639 WP_002262115.1 VTT domain-containing protein -
  SMUNN2025_RS01280 (SmuNN2025_0234) comE/blpR 262505..263257 (+) 753 WP_012997565.1 response regulator transcription factor Regulator
  SMUNN2025_RS01285 (SmuNN2025_0235) comD/blpH 263254..264579 (+) 1326 WP_041160308.1 sensor histidine kinase Regulator
  SMUNN2025_RS01290 (SmuNN2025_0236) comC/blpC 264721..264861 (-) 141 WP_012997567.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  SMUNN2025_RS01295 (SmuNN2025_0237) cipB 265128..265358 (+) 231 WP_012997568.1 Blp family class II bacteriocin Regulator
  SMUNN2025_RS01300 (SmuNN2025_0238) - 265489..265890 (+) 402 WP_002310604.1 hypothetical protein -
  SMUNN2025_RS01305 (SmuNN2025_0240) - 267270..267689 (+) 420 WP_002263913.1 hypothetical protein -
  SMUNN2025_RS01310 (SmuNN2025_0241) - 267836..268240 (+) 405 WP_002263912.1 hypothetical protein -
  SMUNN2025_RS10600 - 268363..268575 (-) 213 Protein_237 IS3 family transposase -
  SMUNN2025_RS10505 - 269015..269179 (+) 165 WP_002265308.1 hypothetical protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 50568.77 Da        Isoelectric Point: 9.8155

>NTDB_id=36570 SMUNN2025_RS01285 WP_041160308.1 263254..264579(+) (comD/blpH) [Streptococcus mutans NN2025]
MNEALMILSNGLLTYLTVLFLLFLFSKVSNVTLSKKELTLFSISNFLIMIAVTMVNVNLFYPTEPLYFIVLSIYLNRQNS
LSLNIFYGLLPVASSDLFRRAIIFFILDGNQGIVMDSSIITTYMIEFAGIALSYLFLSVFNVDIGRLKDSLTKMKVKKRL
IPMNITMLLYYLLIQALYIIESYNVIPTLKFRKFVVIVYLILFLILISFLSQYTKQKVQNEIMAQKEAQIRNITQYSQQI
ESLYKDIRSFRHDYLNILTSLRLGIENKDLASIEKIYHQILEKTGHQLQDTRYNIGHLANIQNDAVKGILSAKILEAQNK
KIAVNVEVSGKIQLPDMELLDFITILSILCDNAIEAALESLKPEIQLAFFKKNGSIVFIIQNSSKEKQIDVSKIFKENYS
TKGSNRGIGLAKVNHILEHYPKTSLQTSSHHHLFKQLLIMK

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=36570 SMUNN2025_RS01285 WP_041160308.1 263254..264579(+) (comD/blpH) [Streptococcus mutans NN2025]
ATGAATGAAGCCTTAATGATACTTTCAAATGGTTTATTAACTTATCTAACCGTTCTATTTCTCTTGTTTCTATTTTCTAA
GGTAAGTAATGTCACTTTATCGAAAAAGGAATTAACTCTTTTTTCGATAAGCAATTTTCTGATAATGATTGCTGTTACGA
TGGTAAATGTAAACCTGTTTTATCCTACAGAGCCTCTTTATTTTATAGTTTTATCAATTTATCTTAATAGACAGAATAGT
CTTTCTCTAAATATATTTTATGGTCTGCTGCCTGTTGCCAGTTCTGACTTGTTTAGGCGGGCAATCATATTCTTTATCTT
GGATGGAAATCAAGGAATTGTAATGGACAGTAGCATTATAACCACCTATATGATCGAGTTTGCAGGAATAGCGCTAAGTT
ACCTCTTTCTAAGTGTGTTCAATGTTGATATTGGTCGACTTAAAGATAGTTTGACCAAGATGAAGGTCAAAAAACGCTTG
ATCCCAATGAATATTACTATGCTTCTATACTACCTTTTAATACAGGCATTGTATATTATAGAGAGTTATAATGTGATACC
GACTTTAAAATTTCGTAAATTTGTCGTTATTGTCTATCTTATTTTATTTTTGATTCTGATCTCATTTTTAAGCCAATATA
CCAAACAAAAGGTTCAAAATGAGATAATGGCACAAAAGGAAGCTCAGATTCGAAATATCACCCAGTATAGTCAGCAAATA
GAATCTCTTTACAAGGATATTCGAAGTTTCCGCCATGATTATCTGAATATTTTAACTAGCCTCAGATTAGGCATTGAAAA
TAAAGATTTAGCTAGTATTGAAAAGATTTACCACCAAATCTTAGAAAAAACAGGACATCAATTGCAGGATACCCGTTATA
ATATCGGCCATCTAGCTAATATTCAAAACGATGCTGTCAAGGGTATCTTATCAGCAAAAATCTTAGAAGCTCAAAATAAA
AAAATTGCTGTCAATGTAGAGGTCTCAGGTAAAATACAGCTGCCTGATATGGAGTTGCTTGATTTCATTACTATACTTTC
TATCTTGTGCGATAATGCTATTGAGGCCGCTCTCGAATCACTAAAACCTGAAATTCAGTTAGCCTTTTTTAAGAAAAATG
GCAGCATAGTCTTTATCATCCAGAATTCCTCCAAAGAAAAACAAATAGATGTGAGTAAAATTTTTAAAGAAAACTATTCC
ACTAAAGGCTCCAATCGCGGTATTGGTTTAGCAAAGGTGAATCATATTCTTGAACATTATCCCAAAACCAGTTTACAAAC
AAGCAGTCATCATCATTTATTCAAGCAACTCCTAATAATGAAATAG

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(337-440)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/blpH Streptococcus mutans UA159

97.052

100

0.971

Multiple sequence alignment