Detailed information NTG0036350

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SMI_RS10500
• Genome accession: NC_013853
• Coordinates: 2141248..2142000 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866062.1
• Uniprot ID: A0A6H3SL01
• Organism: Streptococcus mitis B6
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2136248..2147000

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS10480 (smi_2079)	-	2137694..2140336 (-)	2643	WP_000472055.1	YhgE/Pip domain-containing protein	-
SMI_RS10485 (smi_2080)	-	2140464..2141006 (+)	543	WP_001158276.1	TetR/AcrR family transcriptional regulator	-
SMI_RS10500 (smi_2083)	comE	2141248..2142000 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
SMI_RS10505 (smi_2084)	comD/comD1	2141997..2143322 (-)	1326	WP_012972628.1	competence system sensor histidine kinase ComD	Regulator
SMI_RS10510 (smi_2085)	comC/comC2	2143335..2143457 (-)	123	WP_000799698.1	competence-stimulating peptide ComC	Regulator
SMI_RS10520 (smi_2087)	rlmH	2143739..2144218 (-)	480	WP_000695939.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SMI_RS10525 (smi_2088)	htrA	2144402..2145583 (+)	1182	WP_000681606.1	S1C family serine protease	Regulator
SMI_RS10530 (smi_2089)	spo0J	2145641..2146399 (+)	759	WP_000410369.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29940.28 Da
• Isoelectric Point: 6.5073

>NTDB_id=36350 SMI_RS10500 WP_000866062.1 2141248..2142000(-) (comE) [Streptococcus mitis B6]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=36350 SMI_RS10500 WP_000866062.1 2141248..2142000(-) (comE) [Streptococcus mitis B6]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGACGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACAAGTCGATCAGAGTTTGCAACTCTAACCTATAAATATCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTATTTAAGAAGAGAATTGAGCAAAATATATTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAAAATTTTGCAAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGAGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A6H3SL01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	99.6	100	0.996
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408