Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SMI_RS10505 Genome accession   NC_013853
Coordinates   2141997..2143322 (-) Length   441 a.a.
NCBI ID   WP_012972628.1    Uniprot ID   D3HBR8
Organism   Streptococcus mitis B6     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2136997..2148322
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS10480 (smi_2079) - 2137694..2140336 (-) 2643 WP_000472055.1 YhgE/Pip domain-containing protein -
  SMI_RS10485 (smi_2080) - 2140464..2141006 (+) 543 WP_001158276.1 TetR/AcrR family transcriptional regulator -
  SMI_RS10500 (smi_2083) comE 2141248..2142000 (-) 753 WP_000866062.1 competence system response regulator transcription factor ComE Regulator
  SMI_RS10505 (smi_2084) comD/comD1 2141997..2143322 (-) 1326 WP_012972628.1 competence system sensor histidine kinase ComD Regulator
  SMI_RS10510 (smi_2085) comC/comC2 2143335..2143457 (-) 123 WP_000799698.1 competence-stimulating peptide ComC Regulator
  SMI_RS10520 (smi_2087) rlmH 2143739..2144218 (-) 480 WP_000695939.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SMI_RS10525 (smi_2088) htrA 2144402..2145583 (+) 1182 WP_000681606.1 S1C family serine protease Regulator
  SMI_RS10530 (smi_2089) spo0J 2145641..2146399 (+) 759 WP_000410369.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51136.55 Da        Isoelectric Point: 6.4344

>NTDB_id=36351 SMI_RS10505 WP_012972628.1 2141997..2143322(-) (comD/comD1) [Streptococcus mitis B6]
MDFFLVVDFILYFLILSHSYHLICKGQIKAKELYVFGAYTLLVEAVLELPFYFLSLDGLGIVTFLFPLGLYSYFRWIKQY
ERDRGLFISLLLSLLYESTHNFLSVTFSSITGDNFVLQYYGLFFLAISTLTYFVVLKIIHYFHLELAYFDKDYLYPFLKK
VFFALLLLHLLSFVSDIVSTIKHLNSFGSILSSIVFISLFLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITNLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=36351 SMI_RS10505 WP_012972628.1 2141997..2143322(-) (comD/comD1) [Streptococcus mitis B6]
ATGGATTTTTTCTTAGTAGTGGATTTTATATTATATTTTCTAATTCTTAGTCACAGTTACCATTTAATTTGTAAAGGTCA
AATAAAAGCAAAGGAACTATACGTTTTTGGTGCTTATACATTACTAGTAGAAGCAGTACTTGAACTTCCCTTCTATTTTC
TATCTTTAGATGGGTTAGGAATTGTAACATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATCAAACAGTAT
GAGAGGGATAGAGGACTATTCATAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTGACTTT
CTCCTCTATAACAGGAGACAATTTTGTTTTACAATATTATGGCCTATTCTTTTTAGCAATCTCAACGTTGACCTATTTTG
TTGTCTTAAAAATCATTCATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTTTTGAAAAAA
GTATTTTTTGCTTTACTATTGTTACATCTTTTATCTTTCGTTTCAGATATAGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATTTCTCTATTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAAAACTACACAGATGAAATTGTTGGCTTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGGATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTAGTTAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTAGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACTAATCTTCCAATTGAACTATTGGATTTGGTTCGTATTATGAGTGTTTTATTGAA
CAATGCTGTCGAAGGATCTGCTGATAGTTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTAGGATTAAATAATGTGAAAGAATTATTAGATAAGTACAATAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3HBR8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

90.249

100

0.902
  comD/comD1 Streptococcus pneumoniae D39

90.249

100

0.902
  comD/comD1 Streptococcus pneumoniae R6

90.249

100

0.902
  comD/comD2 Streptococcus pneumoniae TIGR4

90.023

100

0.9
  comD Streptococcus mitis SK321

89.569

100

0.896
  comD Streptococcus mitis NCTC 12261

86.168

100

0.862
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.077

85.941

0.422
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422

Multiple sequence alignment