Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   SMI_RS10510 Genome accession   NC_013853
Coordinates   2143335..2143457 (-) Length   40 a.a.
NCBI ID   WP_000799698.1    Uniprot ID   O33666
Organism   Streptococcus mitis B6     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2138335..2148457
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS10485 (smi_2080) - 2140464..2141006 (+) 543 WP_001158276.1 TetR/AcrR family transcriptional regulator -
  SMI_RS10500 (smi_2083) comE 2141248..2142000 (-) 753 WP_000866062.1 competence system response regulator transcription factor ComE Regulator
  SMI_RS10505 (smi_2084) comD/comD1 2141997..2143322 (-) 1326 WP_012972628.1 competence system sensor histidine kinase ComD Regulator
  SMI_RS10510 (smi_2085) comC/comC2 2143335..2143457 (-) 123 WP_000799698.1 competence-stimulating peptide ComC Regulator
  SMI_RS10520 (smi_2087) rlmH 2143739..2144218 (-) 480 WP_000695939.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SMI_RS10525 (smi_2088) htrA 2144402..2145583 (+) 1182 WP_000681606.1 S1C family serine protease Regulator
  SMI_RS10530 (smi_2089) spo0J 2145641..2146399 (+) 759 WP_000410369.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 40 a.a.        Molecular weight: 4748.68 Da        Isoelectric Point: 11.1475

>NTDB_id=36352 SMI_RS10510 WP_000799698.1 2143335..2143457(-) (comC/comC2) [Streptococcus mitis B6]
MKNTVKLEQFVALKEKELQKIKGGEMRKPDGALFNLFRRR

Nucleotide


Download         Length: 123 bp        

>NTDB_id=36352 SMI_RS10510 WP_000799698.1 2143335..2143457(-) (comC/comC2) [Streptococcus mitis B6]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCCTTGAAGGAAAAAGAATTGCAAAAGATTAAAGGTGGGGAGATGAG
GAAACCAGATGGTGCTTTATTTAATTTATTTAGAAGAAGATAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-27)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB O33666

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

75

100

0.75
  comC/comC2 Streptococcus pneumoniae TIGR4

75

100

0.75
  comC/comC1 Streptococcus pneumoniae G54

96.296

67.5

0.65
  comC/comC1 Streptococcus pneumoniae R6

96.296

67.5

0.65
  comC/comC1 Streptococcus pneumoniae D39

96.296

67.5

0.65
  comC/comC1 Streptococcus pneumoniae Rx1

96.296

67.5

0.65
  comC Streptococcus mitis SK321

82.759

72.5

0.6
  comC Streptococcus mitis NCTC 12261

60

100

0.6

Multiple sequence alignment