Detailed information NTG0036353

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SMI_RS10525
• Genome accession: NC_013853
• Coordinates: 2144402..2145583 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681606.1
• Uniprot ID: D3HBS1
• Organism: Streptococcus mitis B6
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2139402..2150583

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS10485 (smi_2080)	-	2140464..2141006 (+)	543	WP_001158276.1	TetR/AcrR family transcriptional regulator	-
SMI_RS10500 (smi_2083)	comE	2141248..2142000 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
SMI_RS10505 (smi_2084)	comD/comD1	2141997..2143322 (-)	1326	WP_012972628.1	competence system sensor histidine kinase ComD	Regulator
SMI_RS10510 (smi_2085)	comC/comC2	2143335..2143457 (-)	123	WP_000799698.1	competence-stimulating peptide ComC	Regulator
SMI_RS10520 (smi_2087)	rlmH	2143739..2144218 (-)	480	WP_000695939.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SMI_RS10525 (smi_2088)	htrA	2144402..2145583 (+)	1182	WP_000681606.1	S1C family serine protease	Regulator
SMI_RS10530 (smi_2089)	spo0J	2145641..2146399 (+)	759	WP_000410369.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41823.71 Da
• Isoelectric Point: 6.1470

>NTDB_id=36353 SMI_RS10525 WP_000681606.1 2144402..2145583(+) (htrA) [Streptococcus mitis B6]
MKHLKTFYKKWFQLLVVIVISFFSGALGSLSITQLTQKSCVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=36353 SMI_RS10525 WP_000681606.1 2144402..2145583(+) (htrA) [Streptococcus mitis B6]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGGAGTCTTTCAATAACTCAACTAACTCAAAAAAGTTGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCAGCT
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGATACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTAACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCTGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGTAAGTTAACCGTAGGAGAAACTGCCATTGCTATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATAGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATTCAAGGACAAGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTGGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAGAGCAATATGCCTGCTAATGGTCATCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: D3HBS1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	98.219	100	0.982
htrA	Streptococcus pneumoniae D39	98.219	100	0.982
htrA	Streptococcus pneumoniae R6	98.219	100	0.982
htrA	Streptococcus pneumoniae TIGR4	98.219	100	0.982
htrA	Streptococcus mitis NCTC 12261	98.219	100	0.982
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.569	100	0.547