Detailed information NTG0036278

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: SMI_RS00065
• Genome accession: NC_013853
• Coordinates: 14254..14733 (+)
• Length: 159 a.a.
• NCBI ID: WP_000471943.1
• Uniprot ID: D3H629
• Organism: Streptococcus mitis B6
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	15028..16194	14254..14733	flank	295

Gene organization within MGE regions

Location: 14254..16194

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS00065 (smi_0013)	comX/sigX/comX2/sigX2	14254..14733 (+)	480	WP_000471943.1	transcriptional regulator	Regulator
SMI_RS00070 (smi_0014)	-	15028..16194 (-)	1167	WP_000163009.1	IS30-like element ISSmi1 family transposase	-

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 20048.84 Da
• Isoelectric Point: 7.9419

>NTDB_id=36278 SMI_RS00065 WP_000471943.1 14254..14733(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis B6]
MFKELYKEVQGIVYKCRNEYHLHLWELSDWDQEGMICLHELISREEELVEDIPRLRKYFKTKFRNRILDHIRKQESQKRR
YEKEPYEEVGELSHRISEGGLWLDEYYLFHETLRDYRNKQSKDKQEELERVLRHERFRGRQRVLRDLRIVFKEFDIRTL

Nucleotide

• Length: 480 bp

>NTDB_id=36278 SMI_RS00065 WP_000471943.1 14254..14733(+) (comX/sigX/comX2/sigX2) [Streptococcus mitis B6]
ATGTTTAAAGAATTGTATAAAGAAGTCCAGGGAATTGTGTACAAGTGTAGAAATGAATATCATCTCCATTTATGGGAGTT
ATCTGATTGGGACCAAGAGGGAATGATTTGCTTACATGAATTGATCAGTAGAGAAGAAGAGCTAGTAGAAGATATTCCTC
GTTTACGAAAATACTTCAAAACTAAATTCCGTAATCGAATTTTAGACCATATCCGTAAACAAGAAAGCCAGAAGCGTAGA
TATGAAAAAGAACCCTATGAAGAAGTGGGTGAGCTTAGTCATCGTATAAGCGAGGGAGGTCTGTGGCTAGATGAGTATTA
TCTCTTTCATGAGACACTAAGAGATTATAGAAACAAACAAAGTAAAGACAAACAAGAAGAGTTAGAACGCGTCTTAAGAC
ATGAACGCTTCCGAGGACGACAAAGAGTATTAAGAGACTTACGTATTGTGTTTAAGGAGTTTGATATCCGTACTCTGTAA

Domains

No domain identified.

3D structure

• AlphaFold DB: D3H629

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	96.835	99.371	0.962
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	95.57	99.371	0.95
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	94.304	99.371	0.937
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	93.671	99.371	0.931
comX/comX2	Streptococcus pneumoniae Rx1	90.506	99.371	0.899
comX/comX1	Streptococcus pneumoniae Rx1	90.506	99.371	0.899
comX/comX2	Streptococcus pneumoniae D39	90.506	99.371	0.899
comX/comX1	Streptococcus pneumoniae D39	90.506	99.371	0.899
comX/comX2	Streptococcus pneumoniae R6	90.506	99.371	0.899
comX/comX1	Streptococcus pneumoniae R6	90.506	99.371	0.899
comX/comX2	Streptococcus pneumoniae TIGR4	89.873	99.371	0.893
comX/comX1	Streptococcus pneumoniae TIGR4	89.873	99.371	0.893
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46.405	96.226	0.447
comX/sigX	Streptococcus suis D9	45.752	96.226	0.44
comX/sigX	Streptococcus suis isolate S10	45.752	96.226	0.44
comX/sigX	Streptococcus suis P1/7	45.752	96.226	0.44
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	41.611	93.711	0.39
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	41.611	93.711	0.39
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	41.611	93.711	0.39
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	41.611	93.711	0.39
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	40.789	95.597	0.39
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	40.789	95.597	0.39