Detailed information NTG0362678

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: FD735_RS09765
• Genome accession: NZ_CP040231
• Coordinates: 1893136..1893888 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus sp. 1643
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1888136..1898888

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FD735_RS09745 (FD735_09745)	-	1889575..1892229 (-)	2655	WP_139659085.1	YhgE/Pip domain-containing protein	-
FD735_RS09750 (FD735_09750)	-	1892358..1892900 (+)	543	WP_070569601.1	TetR/AcrR family transcriptional regulator	-
FD735_RS09765 (FD735_09765)	comE	1893136..1893888 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
FD735_RS09770 (FD735_09770)	comD	1893885..1895204 (-)	1320	WP_139659086.1	competence system sensor histidine kinase ComD	Regulator
FD735_RS09775 (FD735_09775)	comC/comC2	1895225..1895350 (-)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
FD735_RS09785 (FD735_09785)	rlmH	1895632..1896111 (-)	480	WP_070569604.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FD735_RS09790 (FD735_09790)	htrA	1896297..1897493 (+)	1197	WP_070569607.1	S1C family serine protease	Regulator
FD735_RS09795 (FD735_09795)	spo0J	1897551..1898309 (+)	759	WP_139659087.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=362678 FD735_RS09765 WP_000866079.1 1893136..1893888(-) (comE) [Streptococcus sp. 1643]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=362678 FD735_RS09765 WP_000866079.1 1893136..1893888(-) (comE) [Streptococcus sp. 1643]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCAGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAATTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACTAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATTAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACTACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCAAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCAATTACTCGTTTAAAAGTCCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4