Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   FD735_RS09770 Genome accession   NZ_CP040231
Coordinates   1893885..1895204 (-) Length   439 a.a.
NCBI ID   WP_139659086.1    Uniprot ID   A0A5B7Y8E2
Organism   Streptococcus sp. 1643     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1888885..1900204
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FD735_RS09745 (FD735_09745) - 1889575..1892229 (-) 2655 WP_139659085.1 YhgE/Pip domain-containing protein -
  FD735_RS09750 (FD735_09750) - 1892358..1892900 (+) 543 WP_070569601.1 TetR/AcrR family transcriptional regulator -
  FD735_RS09765 (FD735_09765) comE 1893136..1893888 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  FD735_RS09770 (FD735_09770) comD 1893885..1895204 (-) 1320 WP_139659086.1 competence system sensor histidine kinase ComD Regulator
  FD735_RS09775 (FD735_09775) comC/comC2 1895225..1895350 (-) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  FD735_RS09785 (FD735_09785) rlmH 1895632..1896111 (-) 480 WP_070569604.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FD735_RS09790 (FD735_09790) htrA 1896297..1897493 (+) 1197 WP_070569607.1 S1C family serine protease Regulator
  FD735_RS09795 (FD735_09795) spo0J 1897551..1898309 (+) 759 WP_139659087.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51199.21 Da        Isoelectric Point: 7.0076

>NTDB_id=362679 FD735_RS09770 WP_139659086.1 1893885..1895204(-) (comD) [Streptococcus sp. 1643]
MDLFGLGIAIFYFLIISKSYEWICKINRKEQIVFFCYTCISVFILEEIITLVFSNSFALSKFLFPLVVYLYLRKLKKSEK
YKAIFISLLLSLLYHSTHTFISVTLSSIIGDEVVLHYKSTFLLAVLLMTYFSILIIIRYFHLDIKYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSEKYTYFDLNNIEDSALRSLIAQSIVYARKNDVEFTL
EVKDIITRLSIDLLDLVRIMSILLNNAVEGAADSYLKQMDVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=362679 FD735_RS09770 WP_139659086.1 1893885..1895204(-) (comD) [Streptococcus sp. 1643]
ATGGATTTATTTGGATTAGGGATAGCTATTTTTTATTTTCTCATCATTAGCAAAAGTTATGAATGGATTTGTAAAATAAA
TAGAAAAGAACAAATTGTTTTTTTCTGTTACACATGTATCTCAGTTTTTATACTTGAAGAAATTATTACACTAGTATTTT
CTAATAGTTTTGCTTTGTCTAAATTTTTATTTCCTTTGGTTGTGTACCTTTATTTAAGAAAGTTAAAGAAGTCTGAAAAA
TACAAAGCTATTTTTATCAGTTTACTACTGTCTTTATTATATCACAGTACTCATACTTTTATATCCGTAACCTTATCTTC
TATAATAGGAGATGAAGTAGTATTACACTATAAAAGTACATTCCTTTTAGCAGTATTGTTGATGACTTATTTTTCTATTC
TAATAATAATCCGTTATTTTCATCTGGATATTAAATATTTTGATAAAGATTATCTGTATCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTATTGTTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGCTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAACATTTACAGACTTATACTGATGAAATTGTGGAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTTAGCATGCAAATGGCGATTGACAGTGGAGATTTACAAGAAAT
TAACAGGGTTTACAATGAAGTCCTAGTAAAAGCAAATCAGAAATTGAGGTCAGAAAAATATACTTATTTTGATTTAAATA
ATATAGAAGATTCTGCTTTACGAAGTTTAATTGCTCAATCGATTGTCTATGCACGAAAAAATGATGTAGAGTTTACATTG
GAAGTAAAGGATATCATTACTAGACTGTCAATAGATTTACTTGATCTTGTTCGTATCATGAGCATTTTATTAAACAATGC
TGTTGAAGGTGCAGCAGATAGTTACTTGAAACAAATGGACGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATAACTATGACGCCTTCAGAGGACCTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTCTAGGACTCAATAATGTCAAAGAGATTTTAGATAAGTATGACAACATTATCTTAGAAACTGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5B7Y8E2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis SK321

74.83

100

0.752
  comD Streptococcus mitis NCTC 12261

74.15

100

0.745
  comD/comD2 Streptococcus pneumoniae TIGR4

73.696

100

0.74
  comD/comD1 Streptococcus pneumoniae R6

73.243

100

0.736
  comD/comD1 Streptococcus pneumoniae Rx1

73.243

100

0.736
  comD/comD1 Streptococcus pneumoniae D39

73.243

100

0.736
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

85.194

0.421
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.649

0.419

Multiple sequence alignment