Detailed information NTG0331805

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EHW89_RS09325
• Genome accession: NZ_CP034543
• Coordinates: 1898386..1899135 (-)
• Length: 249 a.a.
• NCBI ID: WP_126468011.1
• Uniprot ID: A0A3S9MTY8
• Organism: Streptococcus periodonticum strain KCOM 2412
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1893386..1904135

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EHW89_RS09305 (EHW89_09305)	-	1893773..1895395 (+)	1623	WP_126468007.1	ABC-F family ATP-binding cassette domain-containing protein	-
EHW89_RS09310 (EHW89_09310)	-	1895462..1898038 (+)	2577	WP_126468009.1	YfhO family protein	-
EHW89_RS09325 (EHW89_09325)	comE	1898386..1899135 (-)	750	WP_126468011.1	competence system response regulator transcription factor ComE	Regulator
EHW89_RS09330 (EHW89_09330)	comD/comD2	1899135..1900457 (-)	1323	WP_126468013.1	sensor histidine kinase	Regulator
EHW89_RS09335 (EHW89_09335)	-	1900472..1900621 (-)	150	WP_106388355.1	bacteriocin	-
EHW89_RS09345 (EHW89_09345)	rlmH	1900903..1901382 (-)	480	WP_126468015.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EHW89_RS09350 (EHW89_09350)	htrA	1901575..1902765 (+)	1191	WP_003032033.1	S1C family serine protease	Regulator
EHW89_RS09355 (EHW89_09355)	spo0J	1902820..1903587 (+)	768	WP_003032028.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29244.93 Da
• Isoelectric Point: 8.6042

>NTDB_id=331805 EHW89_RS09325 WP_126468011.1 1898386..1899135(-) (comE) [Streptococcus periodonticum strain KCOM 2412]
MKVLVLEDEITHQVRMETTLVEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=331805 EHW89_RS09325 WP_126468011.1 1898386..1899135(-) (comE) [Streptococcus periodonticum strain KCOM 2412]
ATGAAAGTATTAGTATTAGAAGATGAAATTACACATCAAGTAAGAATGGAAACAACTTTGGTAGAGATTGCAAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGAAAAGTAAGGGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACGAAATCAGAATTTGCCACTATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A3S9MTY8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	70.492	97.992	0.691
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.492	97.992	0.691
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.081	99.197	0.398
comE/comE2	Streptococcus equinus JB1	35.798	100	0.369