Detailed information NTG0331807

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EHW89_RS09350
• Genome accession: NZ_CP034543
• Coordinates: 1901575..1902765 (+)
• Length: 396 a.a.
• NCBI ID: WP_003032033.1
• Uniprot ID: I0S836
• Organism: Streptococcus periodonticum strain KCOM 2412
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1896575..1907765

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EHW89_RS09325 (EHW89_09325)	comE	1898386..1899135 (-)	750	WP_126468011.1	competence system response regulator transcription factor ComE	Regulator
EHW89_RS09330 (EHW89_09330)	comD/comD2	1899135..1900457 (-)	1323	WP_126468013.1	sensor histidine kinase	Regulator
EHW89_RS09335 (EHW89_09335)	-	1900472..1900621 (-)	150	WP_106388355.1	bacteriocin	-
EHW89_RS09345 (EHW89_09345)	rlmH	1900903..1901382 (-)	480	WP_126468015.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EHW89_RS09350 (EHW89_09350)	htrA	1901575..1902765 (+)	1191	WP_003032033.1	S1C family serine protease	Regulator
EHW89_RS09355 (EHW89_09355)	spo0J	1902820..1903587 (+)	768	WP_003032028.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41651.61 Da
• Isoelectric Point: 9.4264

>NTDB_id=331807 EHW89_RS09350 WP_003032033.1 1901575..1902765(+) (htrA) [Streptococcus periodonticum strain KCOM 2412]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=331807 EHW89_RS09350 WP_003032033.1 1901575..1902765(+) (htrA) [Streptococcus periodonticum strain KCOM 2412]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

3D structure

• AlphaFold DB: I0S836

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.561	100	0.765
htrA	Streptococcus mitis NCTC 12261	72.544	100	0.727
htrA	Streptococcus pneumoniae Rx1	72.292	100	0.725
htrA	Streptococcus pneumoniae D39	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.292	100	0.725
htrA	Streptococcus pneumoniae TIGR4	72.292	100	0.725
htrA	Streptococcus mutans UA159	55.471	99.242	0.551