Detailed information NTG0331368

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EJF26_RS07210
• Genome accession: NZ_CP034442
• Coordinates: 1442047..1442799 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866080.1
• Uniprot ID: A0A139PEN1
• Organism: Streptococcus oralis subsp. dentisani strain F0392
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1437047..1447799

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EJF26_RS07190	-	1438480..1441134 (-)	2655	WP_000472059.1	YhgE/Pip domain-containing protein	-
EJF26_RS07195	-	1441263..1441805 (+)	543	WP_000665076.1	TetR/AcrR family transcriptional regulator	-
EJF26_RS07210	comE	1442047..1442799 (-)	753	WP_000866080.1	competence system response regulator transcription factor ComE	Regulator
EJF26_RS07215	comD	1442796..1444115 (-)	1320	WP_001048121.1	competence system sensor histidine kinase ComD	Regulator
EJF26_RS07220	comC	1444137..1444262 (-)	126	WP_000799680.1	competence-stimulating peptide ComC	Regulator
EJF26_RS07230	rlmH	1444546..1445025 (-)	480	WP_000694224.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EJF26_RS07235	htrA	1445209..1446399 (+)	1191	WP_000681818.1	S1C family serine protease	Regulator
EJF26_RS07240	spo0J	1446457..1447215 (+)	759	WP_004246572.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29906.27 Da
• Isoelectric Point: 6.9820

>NTDB_id=331368 EJF26_RS07210 WP_000866080.1 1442047..1442799(-) (comE) [Streptococcus oralis subsp. dentisani strain F0392]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=331368 EJF26_RS07210 WP_000866080.1 1442047..1442799(-) (comE) [Streptococcus oralis subsp. dentisani strain F0392]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCGGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCACGGAATTGAGAAAAAGGGCTTTGAAGTGGCACAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACAACAGGTGTTTCTCATAAGTTGCGGATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACAATGACAGA
TATTCAAGAAAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATCAATATTGGAAATGTTAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGCTGTCCCATCACTCGTTTGAAAGTTCGTAAACTG
AAAGATATTCTGGAGAAAAAATCTAAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A139PEN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96.4	100	0.964
comE	Streptococcus mitis SK321	95.6	100	0.956
comE	Streptococcus pneumoniae Rx1	94.8	100	0.948
comE	Streptococcus pneumoniae D39	94.8	100	0.948
comE	Streptococcus pneumoniae R6	94.8	100	0.948
comE	Streptococcus pneumoniae TIGR4	94.8	100	0.948
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	64.4	100	0.644
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64.4	100	0.644
comE/blpR	Streptococcus mutans UA159	40.081	98.8	0.396