Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC   Type   Regulator
Locus tag   EJF26_RS07220 Genome accession   NZ_CP034442
Coordinates   1444137..1444262 (-) Length   41 a.a.
NCBI ID   WP_000799680.1    Uniprot ID   A0A428FUE9
Organism   Streptococcus oralis subsp. dentisani strain F0392     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1439137..1449262
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EJF26_RS07195 - 1441263..1441805 (+) 543 WP_000665076.1 TetR/AcrR family transcriptional regulator -
  EJF26_RS07210 comE 1442047..1442799 (-) 753 WP_000866080.1 competence system response regulator transcription factor ComE Regulator
  EJF26_RS07215 comD 1442796..1444115 (-) 1320 WP_001048121.1 competence system sensor histidine kinase ComD Regulator
  EJF26_RS07220 comC 1444137..1444262 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  EJF26_RS07230 rlmH 1444546..1445025 (-) 480 WP_000694224.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EJF26_RS07235 htrA 1445209..1446399 (+) 1191 WP_000681818.1 S1C family serine protease Regulator
  EJF26_RS07240 spo0J 1446457..1447215 (+) 759 WP_004246572.1 ParB/RepB/Spo0J family partition protein Regulator
  EJF26_RS07245 dnaA 1447438..1448799 (+) 1362 WP_004245972.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4998.87 Da        Isoelectric Point: 10.1884

>NTDB_id=331370 EJF26_RS07220 WP_000799680.1 1444137..1444262(-) (comC) [Streptococcus oralis subsp. dentisani strain F0392]
MKNTVKLEQFKEVTETELQEIRGGEWRIPELIRNLIFPKRK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=331370 EJF26_RS07220 WP_000799680.1 1444137..1444262(-) (comC) [Streptococcus oralis subsp. dentisani strain F0392]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAAACAGAATTGCAGGAGATTCGGGGTGGGGAATGGAG
AATTCCAGAATTAATACGTAATCTTATTTTTCCAAAAAGAAAATAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-27)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A428FUE9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC Streptococcus mitis SK321

58.537

100

0.585
  comC/comC2 Streptococcus pneumoniae A66

53.659

100

0.537
  comC/comC2 Streptococcus pneumoniae TIGR4

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae R6

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae G54

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae D39

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae Rx1

51.22

100

0.512
  comC Streptococcus mitis NCTC 12261

47.5

97.561

0.463
  comC/comC2 Streptococcus gordonii strain NCTC7865

43.243

90.244

0.39

Multiple sequence alignment