Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EJF26_RS07235 Genome accession   NZ_CP034442
Coordinates   1445209..1446399 (+) Length   396 a.a.
NCBI ID   WP_000681818.1    Uniprot ID   F9P260
Organism   Streptococcus oralis subsp. dentisani strain F0392     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1440209..1451399
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EJF26_RS07195 - 1441263..1441805 (+) 543 WP_000665076.1 TetR/AcrR family transcriptional regulator -
  EJF26_RS07210 comE 1442047..1442799 (-) 753 WP_000866080.1 competence system response regulator transcription factor ComE Regulator
  EJF26_RS07215 comD 1442796..1444115 (-) 1320 WP_001048121.1 competence system sensor histidine kinase ComD Regulator
  EJF26_RS07220 comC 1444137..1444262 (-) 126 WP_000799680.1 competence-stimulating peptide ComC Regulator
  EJF26_RS07230 rlmH 1444546..1445025 (-) 480 WP_000694224.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EJF26_RS07235 htrA 1445209..1446399 (+) 1191 WP_000681818.1 S1C family serine protease Regulator
  EJF26_RS07240 spo0J 1446457..1447215 (+) 759 WP_004246572.1 ParB/RepB/Spo0J family partition protein Regulator
  EJF26_RS07245 dnaA 1447438..1448799 (+) 1362 WP_004245972.1 chromosomal replication initiator protein DnaA -
  EJF26_RS07250 dnaN 1448958..1450094 (+) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  EJF26_RS07255 - 1450159..1450353 (+) 195 WP_000285196.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41830.77 Da        Isoelectric Point: 6.5083

>NTDB_id=331371 EJF26_RS07235 WP_000681818.1 1445209..1446399(+) (htrA) [Streptococcus oralis subsp. dentisani strain F0392]
MKHLQTFYKKGVTFLIIILIGFLSGALGSFVTLQLYQKQVSQATNNTTNTVTQTSYKNENATTQAVNKVKDAVVSVITYS
SNRQNSVFGNDETDTDTDSQQVASEGSGVIYKKNGKDAYLVTNTHVIKGASKVDIRLADGTKVPGEIVGSDTFSDIAVVK
ISSEKVTTVAEFGDSSKLNVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSQDGQAISTKAIQTDTAINPGNSGGP
LVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLANIGASDLRKLNIPSSVTS
GVVVKSVQSNMPASGHLEKYDVITKVDDKEISSSTDLQSALYNHSIGDTIKITYYRNGKEETTTVKLDKSTSDLES

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=331371 EJF26_RS07235 WP_000681818.1 1445209..1446399(+) (htrA) [Streptococcus oralis subsp. dentisani strain F0392]
ATGAAACACTTACAAACATTTTACAAAAAAGGAGTTACCTTTCTTATCATCATTCTGATAGGATTTTTGAGTGGTGCCCT
AGGAAGTTTTGTGACACTGCAACTTTATCAAAAACAAGTAAGTCAAGCCACAAATAACACTACAAACACTGTTACTCAGA
CTTCCTACAAAAATGAAAATGCAACAACTCAGGCCGTTAACAAGGTAAAAGATGCCGTTGTGTCGGTCATCACTTATTCA
TCAAATCGGCAAAATAGTGTTTTTGGAAATGACGAGACAGATACGGATACCGACTCTCAACAGGTAGCAAGTGAAGGTTC
TGGTGTTATTTACAAAAAGAATGGGAAAGATGCCTACCTTGTGACAAATACCCACGTTATTAAAGGAGCTTCAAAAGTTG
ATATCCGTTTAGCAGACGGTACAAAAGTTCCTGGTGAAATTGTCGGTTCTGATACGTTCTCTGATATTGCTGTCGTAAAA
ATTTCTTCAGAAAAAGTCACAACCGTAGCAGAATTTGGAGATTCTAGCAAGCTTAATGTCGGAGAAACTGCAATCGCAAT
TGGTAGTCCTCTGGGCTCAGAATATGCCAATACAGTTACCCAAGGAATCATTTCAAGTCTCAATCGAAATGTCTCTCTAA
AATCTCAAGATGGTCAAGCCATTTCTACAAAAGCTATTCAGACAGATACTGCTATTAACCCTGGTAACTCTGGTGGTCCA
CTGGTAAATATTCAAGGACAAGTCATCGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACCTCTGTCGAAGGTCT
TGGTTTTGCAATCCCATCAAATGATGCTCAAAATATTATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGCCCTGCTC
TTGGAATTCAAATGGTTAATTTAGCTAATATCGGAGCTAGTGATCTTAGAAAACTCAATATTCCAAGTAGCGTAACTTCT
GGTGTAGTGGTAAAATCTGTTCAAAGTAATATGCCTGCATCTGGTCACCTTGAAAAATACGACGTTATTACCAAAGTTGA
CGACAAGGAGATTTCTTCGTCAACAGATTTACAGAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAAATCACCT
ACTATCGAAATGGGAAAGAGGAGACTACAACTGTTAAGCTAGATAAAAGTACAAGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(106-251)

PDZ domain (PDZ_2)

(292-387)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P260

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

84.848

100

0.848
  htrA Streptococcus pneumoniae Rx1

83.586

100

0.836
  htrA Streptococcus pneumoniae D39

83.586

100

0.836
  htrA Streptococcus pneumoniae R6

83.586

100

0.836
  htrA Streptococcus pneumoniae TIGR4

83.586

100

0.836
  htrA Streptococcus gordonii str. Challis substr. CH1

65.829

100

0.662
  htrA Streptococcus mutans UA159

54.386

100

0.548

Multiple sequence alignment