Detailed information NTG0295113

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CSB72_RS11060
• Genome accession: NZ_CP029678
• Coordinates: 2074519..2075562 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AR_0216
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2069519..2080562

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSB72_RS11030 (CSB72_2008)	-	2069937..2071193 (-)	1257	WP_001795438.1	aminopeptidase	-
CSB72_RS11035 (CSB72_2009)	-	2071196..2071396 (-)	201	WP_000180461.1	DUF1128 family protein	-
CSB72_RS11040 (CSB72_2010)	-	2071543..2072007 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CSB72_RS11045 (CSB72_2011)	-	2072014..2072289 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CSB72_RS11050 (CSB72_2012)	-	2072567..2073784 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CSB72_RS11055 (CSB72_2013)	vraR	2073900..2074529 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
CSB72_RS11060 (CSB72_2014)	vraS	2074519..2075562 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CSB72_RS11065 (CSB72_2015)	liaF	2075559..2076260 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CSB72_RS11070 (CSB72_2016)	-	2076275..2076661 (-)	387	WP_001110179.1	hypothetical protein	-
CSB72_RS11075 (CSB72_2017)	map	2076878..2077636 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CSB72_RS11090 (CSB72_2018)	-	2078164..2079150 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CSB72_RS11100 (CSB72_2019)	-	2079640..2080053 (-)	414	WP_001549145.1	hypothetical protein	-
CSB72_RS11105	-	2080082..2080192 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=295113 CSB72_RS11060 WP_001017131.1 2074519..2075562(-) (vraS) [Staphylococcus aureus strain AR_0216]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=295113 CSB72_RS11060 WP_001017131.1 2074519..2075562(-) (vraS) [Staphylococcus aureus strain AR_0216]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1