Detailed information NTG0291450

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DG474_RS09545
• Genome accession: NZ_CP029257
• Coordinates: 1996632..1997384 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain CCUG 53468
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1991632..2002384

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DG474_RS09525 (DG474_09675)	-	1993069..1995723 (-)	2655	WP_255778220.1	YhgE/Pip domain-containing protein	-
DG474_RS09530 (DG474_09680)	-	1995852..1996394 (+)	543	WP_000665080.1	TetR/AcrR family transcriptional regulator	-
DG474_RS09545 (DG474_09695)	comE	1996632..1997384 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
DG474_RS09550 (DG474_09700)	comD	1997381..1998700 (-)	1320	WP_255778222.1	competence system sensor histidine kinase ComD	Regulator
DG474_RS09555 (DG474_09705)	comC/comC1	1998721..1998846 (-)	126	WP_008282505.1	competence-stimulating peptide ComC	Regulator
DG474_RS09565 (DG474_09715)	rlmH	1999128..1999607 (-)	480	WP_255778224.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DG474_RS09570 (DG474_09720)	htrA	1999793..2000989 (+)	1197	WP_000681803.1	S1C family serine protease	Regulator
DG474_RS09575 (DG474_09725)	spo0J	2001047..2001805 (+)	759	WP_000410359.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=291450 DG474_RS09545 WP_000866079.1 1996632..1997384(-) (comE) [Streptococcus oralis strain CCUG 53468]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=291450 DG474_RS09545 WP_000866079.1 1996632..1997384(-) (comE) [Streptococcus oralis strain CCUG 53468]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACTTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGTATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4