Detailed information NTG0291453

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DG474_RS09570
• Genome accession: NZ_CP029257
• Coordinates: 1999793..2000989 (+)
• Length: 398 a.a.
• NCBI ID: WP_000681803.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain CCUG 53468
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1994793..2005989

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DG474_RS09530 (DG474_09680)	-	1995852..1996394 (+)	543	WP_000665080.1	TetR/AcrR family transcriptional regulator	-
DG474_RS09545 (DG474_09695)	comE	1996632..1997384 (-)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
DG474_RS09550 (DG474_09700)	comD	1997381..1998700 (-)	1320	WP_255778222.1	competence system sensor histidine kinase ComD	Regulator
DG474_RS09555 (DG474_09705)	comC/comC1	1998721..1998846 (-)	126	WP_008282505.1	competence-stimulating peptide ComC	Regulator
DG474_RS09565 (DG474_09715)	rlmH	1999128..1999607 (-)	480	WP_255778224.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DG474_RS09570 (DG474_09720)	htrA	1999793..2000989 (+)	1197	WP_000681803.1	S1C family serine protease	Regulator
DG474_RS09575 (DG474_09725)	spo0J	2001047..2001805 (+)	759	WP_000410359.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41985.76 Da
• Isoelectric Point: 6.6581

>NTDB_id=291453 DG474_RS09570 WP_000681803.1 1999793..2000989(+) (htrA) [Streptococcus oralis strain CCUG 53468]
MKHLQKFYKKGVKVLAIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNGDETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSSL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSGDLES

Nucleotide

• Length: 1197 bp

>NTDB_id=291453 DG474_RS09570 WP_000681803.1 1999793..2000989(+) (htrA) [Streptococcus oralis strain CCUG 53468]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTTGCAATCATTCTAATAGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACGAATAATAATTCTGGCACTGTCACTCAAA
CATCATATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGGTGATGAAACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAAGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATTCGCTTGGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACTTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGCCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATTGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGAATCATCTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACGGCTATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTAATGGTAAAGTGACTCGTC
CAGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTAGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGACAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATCGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTGGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (210-393)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• PDZ domain (PDZ_2) (294-389)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	83.668	100	0.837
htrA	Streptococcus pneumoniae Rx1	82.915	100	0.829
htrA	Streptococcus pneumoniae D39	82.915	100	0.829
htrA	Streptococcus pneumoniae R6	82.915	100	0.829
htrA	Streptococcus pneumoniae TIGR4	82.915	100	0.829
htrA	Streptococcus gordonii str. Challis substr. CH1	66.915	100	0.676
htrA	Streptococcus mutans UA159	54.822	98.995	0.543