Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   DG474_RS09555 Genome accession   NZ_CP029257
Coordinates   1998721..1998846 (-) Length   41 a.a.
NCBI ID   WP_008282505.1    Uniprot ID   A0A139Q4L7
Organism   Streptococcus oralis strain CCUG 53468     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1993721..2003846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS09530 (DG474_09680) - 1995852..1996394 (+) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -
  DG474_RS09545 (DG474_09695) comE 1996632..1997384 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  DG474_RS09550 (DG474_09700) comD 1997381..1998700 (-) 1320 WP_255778222.1 competence system sensor histidine kinase ComD Regulator
  DG474_RS09555 (DG474_09705) comC/comC1 1998721..1998846 (-) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  DG474_RS09565 (DG474_09715) rlmH 1999128..1999607 (-) 480 WP_255778224.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DG474_RS09570 (DG474_09720) htrA 1999793..2000989 (+) 1197 WP_000681803.1 S1C family serine protease Regulator
  DG474_RS09575 (DG474_09725) spo0J 2001047..2001805 (+) 759 WP_000410359.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4957.73 Da        Isoelectric Point: 10.2767

>NTDB_id=291452 DG474_RS09555 WP_008282505.1 1998721..1998846(-) (comC/comC1) [Streptococcus oralis strain CCUG 53468]
MKNTVKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=291452 DG474_RS09555 WP_008282505.1 1998721..1998846(-) (comC/comC1) [Streptococcus oralis strain CCUG 53468]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAGGTAACAGAGGCAGAATTGCAGGAGATTCGAGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139Q4L7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae G54

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae D39

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae Rx1

53.659

100

0.537
  comC Streptococcus mitis SK321

68.966

70.732

0.488
  comC/comC2 Streptococcus pneumoniae A66

58.621

70.732

0.415
  comC/comC2 Streptococcus pneumoniae TIGR4

58.621

70.732

0.415
  comC Streptococcus mitis NCTC 12261

55.556

65.854

0.366
  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366

Multiple sequence alignment