Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   DG474_RS09550 Genome accession   NZ_CP029257
Coordinates   1997381..1998700 (-) Length   439 a.a.
NCBI ID   WP_255778222.1    Uniprot ID   -
Organism   Streptococcus oralis strain CCUG 53468     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1992381..2003700
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DG474_RS09525 (DG474_09675) - 1993069..1995723 (-) 2655 WP_255778220.1 YhgE/Pip domain-containing protein -
  DG474_RS09530 (DG474_09680) - 1995852..1996394 (+) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -
  DG474_RS09545 (DG474_09695) comE 1996632..1997384 (-) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  DG474_RS09550 (DG474_09700) comD 1997381..1998700 (-) 1320 WP_255778222.1 competence system sensor histidine kinase ComD Regulator
  DG474_RS09555 (DG474_09705) comC/comC1 1998721..1998846 (-) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  DG474_RS09565 (DG474_09715) rlmH 1999128..1999607 (-) 480 WP_255778224.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DG474_RS09570 (DG474_09720) htrA 1999793..2000989 (+) 1197 WP_000681803.1 S1C family serine protease Regulator
  DG474_RS09575 (DG474_09725) spo0J 2001047..2001805 (+) 759 WP_000410359.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 50938.80 Da        Isoelectric Point: 6.3722

>NTDB_id=291451 DG474_RS09550 WP_255778222.1 1997381..1998700(-) (comD) [Streptococcus oralis strain CCUG 53468]
MSLLGFGIVILHIFILTISYELICKVTKKERYLFIACIFVYQSVAEFFFDFISLAGLGIEKFIFPFILYTSILAIKKYDK
HKGMFISLLLSLLYHSTHTFLSVTLSSITGDAFVIEHEVMFYLGVLLLTYFIIKKIITYFHLELTYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSDKYTYFDLNNIEDSALRSLIAQSIVYARNNDVEFTL
EVKDVITRLSMDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=291451 DG474_RS09550 WP_255778222.1 1997381..1998700(-) (comD) [Streptococcus oralis strain CCUG 53468]
ATGAGTTTATTAGGATTTGGAATAGTTATTCTTCATATTTTTATTTTAACAATAAGCTATGAATTAATTTGTAAAGTAAC
TAAAAAAGAAAGATATTTATTTATAGCTTGTATATTTGTATATCAGTCTGTAGCTGAATTTTTCTTTGACTTTATTTCAT
TAGCTGGGTTAGGGATTGAAAAATTTATATTTCCTTTTATTCTATATACTTCTATATTAGCTATAAAGAAGTATGATAAG
CATAAAGGAATGTTTATCAGTTTACTATTGTCTTTATTATATCATAGTACACATACTTTTTTATCAGTAACCCTATCCTC
TATAACAGGTGATGCTTTTGTGATAGAACATGAAGTGATGTTTTATTTAGGAGTACTATTACTAACATATTTTATTATTA
AAAAAATTATTACTTATTTCCACTTAGAACTTACCTATTTTGATAAAGATTATCTGTACCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTACTGTTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGCTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAGCATTTACAGACTTATACTGATGAAATTGTGGAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTCAGCATGCAAATGGCGATTGACAGTGGAGATTTACAAGAAAT
TAACAGAGTTTACAATGAAGTCCTAGTAAAAGCAAATCAGAAATTGAGATCAGACAAATATACTTACTTTGATTTAAATA
ACATAGAAGATTCAGCTTTACGAAGTTTAATTGCTCAATCGATTGTCTATGCTCGAAATAATGATGTAGAGTTTACATTG
GAAGTAAAAGATGTCATTACTAGATTGTCAATGGATTTACTTGATCTTGTTCGTATCATGAGCATTTTATTAAATAATGC
TGTTGAAGGTGCTGCAGATAGTTACTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATCACTATGACGCCTTCAGAGGATTTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTCTAGGACTTAATAATGTCAAGGAGATTTTAGATAAGTATGACAACATTATTTTAGAAACAGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(332-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

76.19

100

0.765
  comD/comD2 Streptococcus pneumoniae TIGR4

74.83

100

0.752
  comD Streptococcus mitis SK321

74.603

100

0.749
  comD/comD1 Streptococcus pneumoniae R6

74.15

100

0.745
  comD/comD1 Streptococcus pneumoniae Rx1

74.15

100

0.745
  comD/comD1 Streptococcus pneumoniae D39

74.15

100

0.745
  comD/comD2 Streptococcus gordonii strain NCTC7865

51.862

85.649

0.444
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

51.337

85.194

0.437

Multiple sequence alignment