Detailed information NTG0291181

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DEH83_RS04465
• Genome accession: NZ_CP029207
• Coordinates: 879578..880327 (+)
• Length: 249 a.a.
• NCBI ID: WP_003071650.1
• Uniprot ID: A0A380L579
• Organism: Streptococcus constellatus strain TCV107
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 874578..885327

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DEH83_RS04435 (DEH83_04420)	spo0J	875111..875878 (-)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator
DEH83_RS04440 (DEH83_04425)	htrA	875933..877123 (-)	1191	WP_006270334.1	S1C family serine protease	Regulator
DEH83_RS04445 (DEH83_04430)	rlmH	877328..877807 (+)	480	WP_255777177.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DEH83_RS04455 (DEH83_04440)	-	878090..878236 (+)	147	WP_006270349.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DEH83_RS04460 (DEH83_04445)	comD/comD2	878253..879578 (+)	1326	WP_304675344.1	sensor histidine kinase	Regulator
DEH83_RS04465 (DEH83_04450)	comE	879578..880327 (+)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
DEH83_RS04480 (DEH83_04465)	-	880646..883225 (-)	2580	WP_255777179.1	YfhO family protein	-
DEH83_RS04485 (DEH83_04470)	-	883299..884921 (-)	1623	WP_003071648.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29171.69 Da
• Isoelectric Point: 8.0453

>NTDB_id=291181 DEH83_RS04465 WP_003071650.1 879578..880327(+) (comE) [Streptococcus constellatus strain TCV107]
MKVLILEDEITHQVRMETTLAEIAKEMGIPIKVKITGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDAAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDEKTQRFFSPHKSYLVNIGNIKGYDKKTREIIFYEDHRCPITRMKIGKL
KSILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=291181 DEH83_RS04465 WP_003071650.1 879578..880327(+) (comE) [Streptococcus constellatus strain TCV107]
ATGAAAGTACTAATATTAGAAGATGAAATTACACATCAAGTTAGAATGGAAACAACATTGGCAGAAATAGCTAAGGAAAT
GGGGATTCCGATAAAAGTTAAAATAACTGGAAAAGTAAGAGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATTAAAGGTGAAGAAACAAAAGGGTTAGAAATAGCCAAATTTATACGGCATCACAATCCT
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACTATGACGTTTAAATATAAAGTATCTGCATTAGATTT
TGTTGATAAAAATTTGAATGATGCTGCTTTTAAAAAACATATAAAAGACAGTATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTCCGTGGTGGCGAAGTTAGAATGCCTTTTAATGATATCTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTTGGTAAAAACTTTTTTAAAGAATTTTATGGTACGATTGCAGA
TATTCAGGAAAAAGACGAGAAAACACAGCGCTTCTTTTCACCTCATAAATCTTATCTAGTTAATATTGGGAATATTAAAG
GTTATGACAAAAAAACAAGAGAAATTATTTTTTATGAAGATCACCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTG
AAATCCATTTTAGAGGAATCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: A0A380L579

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.837	98.394	0.707
comE	Streptococcus infantis strain Atu-4	71.02	98.394	0.699
comE	Streptococcus mitis SK321	71.02	98.394	0.699
comE	Streptococcus pneumoniae Rx1	70.612	98.394	0.695
comE	Streptococcus pneumoniae D39	70.612	98.394	0.695
comE	Streptococcus pneumoniae R6	70.612	98.394	0.695
comE	Streptococcus pneumoniae TIGR4	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	69.672	97.992	0.683
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.672	97.992	0.683
comE/blpR	Streptococcus mutans UA159	39.759	100	0.398
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361