Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   DEH83_RS04440 Genome accession   NZ_CP029207
Coordinates   875933..877123 (-) Length   396 a.a.
NCBI ID   WP_006270334.1    Uniprot ID   U2XXY1
Organism   Streptococcus constellatus strain TCV107     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 870933..882123
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DEH83_RS04415 (DEH83_04400) - 871462..871962 (+) 501 WP_006268820.1 YehR family lipoprotein -
  DEH83_RS04420 (DEH83_04405) - 872049..872246 (-) 198 WP_003071662.1 DUF951 domain-containing protein -
  DEH83_RS04425 (DEH83_04410) dnaN 872246..873382 (-) 1137 WP_048800763.1 DNA polymerase III subunit beta -
  DEH83_RS04430 (DEH83_04415) dnaA 873539..874882 (-) 1344 WP_006270358.1 chromosomal replication initiator protein DnaA -
  DEH83_RS04435 (DEH83_04420) spo0J 875111..875878 (-) 768 WP_003071657.1 ParB/RepB/Spo0J family partition protein Regulator
  DEH83_RS04440 (DEH83_04425) htrA 875933..877123 (-) 1191 WP_006270334.1 S1C family serine protease Regulator
  DEH83_RS04445 (DEH83_04430) rlmH 877328..877807 (+) 480 WP_255777177.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DEH83_RS04455 (DEH83_04440) - 878090..878236 (+) 147 WP_006270349.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  DEH83_RS04460 (DEH83_04445) comD/comD2 878253..879578 (+) 1326 WP_304675344.1 sensor histidine kinase Regulator
  DEH83_RS04465 (DEH83_04450) comE 879578..880327 (+) 750 WP_003071650.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41637.72 Da        Isoelectric Point: 9.8633

>NTDB_id=291179 DEH83_RS04440 WP_006270334.1 875933..877123(-) (htrA) [Streptococcus constellatus strain TCV107]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSNSDLSRLKLPSKVTSGV
VVRSAQAGMPAAGKLQKYDVITKVDGKDISSVSDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=291179 DEH83_RS04440 WP_006270334.1 875933..877123(-) (htrA) [Streptococcus constellatus strain TCV107]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCTACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTGGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAATAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAGTTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACTATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATTGCTAGCAACGGTGGAACTTCTGTTGAGGGATTAGGTTT
TGCCATTCCATCTAATGATGTTATTAATATTATCAATCAATTAGAAGCAAACGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATCGACATCACTAATCTGTCTAATTCAGATTTATCACGCTTAAAACTCCCATCCAAAGTAACTAGTGGGGTT
GTTGTACGTTCAGCTCAAGCTGGGATGCCTGCAGCAGGAAAGCTTCAAAAATATGATGTTATTACAAAAGTAGATGGCAA
AGACATTTCCTCAGTAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACAACTACTATTAAGCTGACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)

Peptidase family M50 (Peptidase_M50)

(266-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2XXY1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

74.25

100

0.75
  htrA Streptococcus mitis NCTC 12261

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.04

100

0.722
  htrA Streptococcus pneumoniae TIGR4

72.04

100

0.722
  htrA Streptococcus pneumoniae D39

72.04

100

0.722
  htrA Streptococcus pneumoniae Rx1

72.04

100

0.722
  htrA Streptococcus mutans UA159

55.838

99.495

0.556

Multiple sequence alignment