Detailed information NTG0284741

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SK637_RS09655
• Genome accession: NZ_CP028415
• Coordinates: 1936859..1937611 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866062.1
• Uniprot ID: A0A6H3SL01
• Organism: Streptococcus mitis strain SK637
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1931859..1942611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SK637_RS09635 (SK637_01878)	-	1933304..1935946 (-)	2643	WP_033689605.1	YhgE/Pip domain-containing protein	-
SK637_RS09640 (SK637_01879)	-	1936074..1936616 (+)	543	WP_033689607.1	TetR/AcrR family transcriptional regulator	-
SK637_RS09655 (SK637_01882)	comE	1936859..1937611 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
SK637_RS09660 (SK637_01883)	comD/comD1	1937608..1938933 (-)	1326	WP_033689609.1	competence system sensor histidine kinase ComD	Regulator
SK637_RS09665 (SK637_01884)	comC/comC2	1938946..1939068 (-)	123	WP_033689611.1	competence-stimulating peptide ComC	Regulator
SK637_RS09675 (SK637_01886)	rlmH	1939350..1939829 (-)	480	WP_000695939.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SK637_RS09680 (SK637_01887)	htrA	1940013..1941197 (+)	1185	WP_033689613.1	S1C family serine protease	Regulator
SK637_RS09685 (SK637_01888)	spo0J	1941255..1942013 (+)	759	WP_033689615.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29940.28 Da
• Isoelectric Point: 6.5073

>NTDB_id=284741 SK637_RS09655 WP_000866062.1 1936859..1937611(-) (comE) [Streptococcus mitis strain SK637]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=284741 SK637_RS09655 WP_000866062.1 1936859..1937611(-) (comE) [Streptococcus mitis strain SK637]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGACGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACAAGTCGATCAGAGTTTGCGACTCTAACATATAAATATCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTATTTAAGAAGAGAATTGAGCAAAATATATTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAAAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGAGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A6H3SL01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	99.6	100	0.996
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408