Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   SK637_RS09665 Genome accession   NZ_CP028415
Coordinates   1938946..1939068 (-) Length   40 a.a.
NCBI ID   WP_033689611.1    Uniprot ID   O33668
Organism   Streptococcus mitis strain SK637     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1933946..1944068
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS09640 (SK637_01879) - 1936074..1936616 (+) 543 WP_033689607.1 TetR/AcrR family transcriptional regulator -
  SK637_RS09655 (SK637_01882) comE 1936859..1937611 (-) 753 WP_000866062.1 competence system response regulator transcription factor ComE Regulator
  SK637_RS09660 (SK637_01883) comD/comD1 1937608..1938933 (-) 1326 WP_033689609.1 competence system sensor histidine kinase ComD Regulator
  SK637_RS09665 (SK637_01884) comC/comC2 1938946..1939068 (-) 123 WP_033689611.1 competence-stimulating peptide ComC Regulator
  SK637_RS09675 (SK637_01886) rlmH 1939350..1939829 (-) 480 WP_000695939.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SK637_RS09680 (SK637_01887) htrA 1940013..1941197 (+) 1185 WP_033689613.1 S1C family serine protease Regulator
  SK637_RS09685 (SK637_01888) spo0J 1941255..1942013 (+) 759 WP_033689615.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 40 a.a.        Molecular weight: 4837.68 Da        Isoelectric Point: 11.0668

>NTDB_id=284743 SK637_RS09665 WP_033689611.1 1938946..1939068(-) (comC/comC2) [Streptococcus mitis strain SK637]
MKNTVKLEQFVALKEKDLQKIQGGEMRKSNNNFFHFLRRI

Nucleotide


Download         Length: 123 bp        

>NTDB_id=284743 SK637_RS09665 WP_033689611.1 1938946..1939068(-) (comC/comC2) [Streptococcus mitis strain SK637]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCCTTGAAGGAAAAAGACTTGCAAAAAATTCAAGGTGGGGAGATGAG
GAAATCAAATAATAATTTCTTTCATTTCTTAAGAAGAATATAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB O33668

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

77.5

100

0.775
  comC/comC2 Streptococcus pneumoniae TIGR4

77.5

100

0.775
  comC Streptococcus mitis SK321

72.5

100

0.725
  comC/comC1 Streptococcus pneumoniae R6

93.103

72.5

0.675
  comC/comC1 Streptococcus pneumoniae G54

93.103

72.5

0.675
  comC/comC1 Streptococcus pneumoniae D39

93.103

72.5

0.675
  comC/comC1 Streptococcus pneumoniae Rx1

93.103

72.5

0.675
  comC Streptococcus mitis NCTC 12261

66.667

97.5

0.65

Multiple sequence alignment