Detailed information NTG0284744

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SK637_RS09680
• Genome accession: NZ_CP028415
• Coordinates: 1940013..1941197 (+)
• Length: 394 a.a.
• NCBI ID: WP_033689613.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain SK637
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 1935013..1946197

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SK637_RS09640 (SK637_01879)	-	1936074..1936616 (+)	543	WP_033689607.1	TetR/AcrR family transcriptional regulator	-
SK637_RS09655 (SK637_01882)	comE	1936859..1937611 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
SK637_RS09660 (SK637_01883)	comD/comD1	1937608..1938933 (-)	1326	WP_033689609.1	competence system sensor histidine kinase ComD	Regulator
SK637_RS09665 (SK637_01884)	comC/comC2	1938946..1939068 (-)	123	WP_033689611.1	competence-stimulating peptide ComC	Regulator
SK637_RS09675 (SK637_01886)	rlmH	1939350..1939829 (-)	480	WP_000695939.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SK637_RS09680 (SK637_01887)	htrA	1940013..1941197 (+)	1185	WP_033689613.1	S1C family serine protease	Regulator
SK637_RS09685 (SK637_01888)	spo0J	1941255..1942013 (+)	759	WP_033689615.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 394 a.a.
• Molecular weight: 41983.83 Da
• Isoelectric Point: 6.1485

>NTDB_id=284744 SK637_RS09680 WP_033689613.1 1940013..1941197(+) (htrA) [Streptococcus mitis strain SK637]
MKHLKTFYKKWFQLLVVIVISFFSGALGSLSITQLTQKSGVNNSNNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYS
ANRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKIS
SEKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLI
NIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTYGV
VVRSVQSNMPANGHLEKYDVITKVDDKEISSSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1185 bp

>NTDB_id=284744 SK637_RS09680 WP_033689613.1 1940013..1941197(+) (htrA) [Streptococcus mitis strain SK637]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGGAGTCTTTCAATAACTCAACTAACTCAAAAAAGTGGTGTAAATAACTCTAACAACAACAATAGTACTATTACACAAA
CTGCCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCA
GCTAACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGT
TATTTATAAAAAGAATGATAAAGAAGCTTACATCGTAACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTC
GTTTGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCTGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCT
TCAGAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGTAAGTTAACCGTAGGAGAAACTGCCATTGCTATTGGTAG
CCCATTGGGTTCTGAATATGCAAATACTGTCACTCAGGGTATTGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTG
AAGATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATC
AATATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTT
CGCAATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGTAAAGTGACTCGTCCAGCTTTGGGAA
TTCAAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTTAATATTCCAAGCAATGTAACATATGGTGTA
GTTGTTCGTTCTGTGCAGAGCAATATGCCTGCTAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAA
AGAGATTTCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATCACTTACTATC
GCAACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	97.462	100	0.975
htrA	Streptococcus pneumoniae D39	97.462	100	0.975
htrA	Streptococcus pneumoniae R6	97.462	100	0.975
htrA	Streptococcus pneumoniae TIGR4	97.462	100	0.975
htrA	Streptococcus mitis NCTC 12261	97.208	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.668
htrA	Streptococcus mutans UA159	54.177	100	0.543