Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SK637_RS09660 Genome accession   NZ_CP028415
Coordinates   1937608..1938933 (-) Length   441 a.a.
NCBI ID   WP_033689609.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1932608..1943933
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS09635 (SK637_01878) - 1933304..1935946 (-) 2643 WP_033689605.1 YhgE/Pip domain-containing protein -
  SK637_RS09640 (SK637_01879) - 1936074..1936616 (+) 543 WP_033689607.1 TetR/AcrR family transcriptional regulator -
  SK637_RS09655 (SK637_01882) comE 1936859..1937611 (-) 753 WP_000866062.1 competence system response regulator transcription factor ComE Regulator
  SK637_RS09660 (SK637_01883) comD/comD1 1937608..1938933 (-) 1326 WP_033689609.1 competence system sensor histidine kinase ComD Regulator
  SK637_RS09665 (SK637_01884) comC/comC2 1938946..1939068 (-) 123 WP_033689611.1 competence-stimulating peptide ComC Regulator
  SK637_RS09675 (SK637_01886) rlmH 1939350..1939829 (-) 480 WP_000695939.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SK637_RS09680 (SK637_01887) htrA 1940013..1941197 (+) 1185 WP_033689613.1 S1C family serine protease Regulator
  SK637_RS09685 (SK637_01888) spo0J 1941255..1942013 (+) 759 WP_033689615.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51233.77 Da        Isoelectric Point: 6.5778

>NTDB_id=284742 SK637_RS09660 WP_033689609.1 1937608..1938933(-) (comD/comD1) [Streptococcus mitis strain SK637]
MDFFLVVDFILYFLIISHSYHLICKDQIKAKELYIFGAYTLLLQIVLGLPFYLLSLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESPHTFLSVTFSSITGDNFVLQYYGLFFFVVTVLTYFIILKIIHYFHLELNYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTVKHLNSFGSILSSIVFISLFLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITNLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=284742 SK637_RS09660 WP_033689609.1 1937608..1938933(-) (comD/comD1) [Streptococcus mitis strain SK637]
ATGGATTTTTTCTTAGTAGTAGATTTTATATTATATTTTTTAATTATTAGTCACAGTTACCATTTAATTTGTAAAGATCA
AATAAAAGCAAAGGAATTATACATTTTTGGTGCTTATACACTACTATTACAAATAGTCCTTGGTCTTCCCTTTTATCTTC
TATCTTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGATTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGTCCTCACACCTTTCTGTCCGTAACGTT
CTCCTCTATAACAGGAGACAATTTTGTTTTACAATATTATGGGTTATTCTTTTTCGTTGTAACGGTGTTGACCTATTTTA
TTATCTTAAAAATCATTCATTATTTCCATTTAGAACTAAACTATTTTGATAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTACTGCTCCATATTGTATCGTTCGTTTCAGATATGGTAAGTACGGTTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATTTCTCTATTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAAAACTACACAGATGAAATTGTCGGACTGTAT
AATGAAATTCGTGGTTTTCGACATGACTATGCTGGAATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTAGTTAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTAGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACTAATCTTCCAATTGAACTATTGGATTTGGTTCGTATTATGAGTGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGTTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTAGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAACATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae D39

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae Rx1

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae R6

90.93

100

0.909
  comD Streptococcus mitis SK321

90.703

100

0.907
  comD/comD2 Streptococcus pneumoniae TIGR4

90.703

100

0.907
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

50.266

85.261

0.429
  comD/comD2 Streptococcus gordonii strain NCTC7865

50

85.261

0.426

Multiple sequence alignment