Detailed information NTG0247889

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: CO686_RS09115
• Genome accession: NZ_CP023507
• Coordinates: 1860515..1861267 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866082.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain FDAARGOS_367
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1855515..1866267

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CO686_RS09095 (CO686_09095)	-	1856949..1859603 (-)	2655	WP_049550155.1	YhgE/Pip domain-containing protein	-
CO686_RS09100 (CO686_09100)	-	1859732..1860274 (+)	543	WP_000665077.1	TetR-like C-terminal domain-containing protein	-
CO686_RS09115 (CO686_09115)	comE	1860515..1861267 (-)	753	WP_000866082.1	competence system response regulator transcription factor ComE	Regulator
CO686_RS09120 (CO686_09120)	comD	1861264..1862583 (-)	1320	WP_049550146.1	competence system sensor histidine kinase ComD	Regulator
CO686_RS09125 (CO686_09125)	comC/comC2	1862604..1862729 (-)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
CO686_RS09135 (CO686_09135)	rlmH	1863011..1863490 (-)	480	WP_000694219.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
CO686_RS09140 (CO686_09140)	htrA	1863676..1864872 (+)	1197	WP_000681804.1	S1C family serine protease	Regulator
CO686_RS09145 (CO686_09145)	spo0J	1864930..1865688 (+)	759	WP_002881154.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29910.27 Da
• Isoelectric Point: 6.9162

>NTDB_id=247889 CO686_RS09115 WP_000866082.1 1860515..1861267(-) (comE) [Streptococcus oralis strain FDAARGOS_367]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIYGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=247889 CO686_RS09115 WP_000866082.1 1860515..1861267(-) (comE) [Streptococcus oralis strain FDAARGOS_367]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCTGAGGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTTATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGTTTATTCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTCGCTACTTTAACTTATAAGTATCAGGTATCAGCTTTAGATTT
TGTAGATAAGGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATTCCTTACCATGATATTCTGTAT
ATCGAAACAACAGGTGTTTCTCATAAATTGCGAATTATTGGTAAGAATTTTGCCAAAGAGTTTTATGGAACTATGACAGA
TATTCAGGAGAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTAGGAAATGTGAGAG
AAATTGATCGAAAAAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCTATTACCCGTTTGAAAGTTCGTAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.2	100	0.952
comE	Streptococcus mitis SK321	94.4	100	0.944
comE	Streptococcus pneumoniae Rx1	93.6	100	0.936
comE	Streptococcus pneumoniae D39	93.6	100	0.936
comE	Streptococcus pneumoniae R6	93.6	100	0.936
comE	Streptococcus pneumoniae TIGR4	93.6	100	0.936
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4