Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   CO686_RS09140 Genome accession   NZ_CP023507
Coordinates   1863676..1864872 (+) Length   398 a.a.
NCBI ID   WP_000681804.1    Uniprot ID   A0AAW7W8H8
Organism   Streptococcus oralis strain FDAARGOS_367     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1858676..1869872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO686_RS09100 (CO686_09100) - 1859732..1860274 (+) 543 WP_000665077.1 TetR-like C-terminal domain-containing protein -
  CO686_RS09115 (CO686_09115) comE 1860515..1861267 (-) 753 WP_000866082.1 competence system response regulator transcription factor ComE Regulator
  CO686_RS09120 (CO686_09120) comD 1861264..1862583 (-) 1320 WP_049550146.1 competence system sensor histidine kinase ComD Regulator
  CO686_RS09125 (CO686_09125) comC/comC2 1862604..1862729 (-) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  CO686_RS09135 (CO686_09135) rlmH 1863011..1863490 (-) 480 WP_000694219.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  CO686_RS09140 (CO686_09140) htrA 1863676..1864872 (+) 1197 WP_000681804.1 S1C family serine protease Regulator
  CO686_RS09145 (CO686_09145) spo0J 1864930..1865688 (+) 759 WP_002881154.1 ParB/RepB/Spo0J family partition protein Regulator
  CO686_RS09150 (CO686_09150) dnaA 1865906..1867267 (+) 1362 WP_000660630.1 chromosomal replication initiator protein DnaA -
  CO686_RS09155 (CO686_09155) dnaN 1867426..1868562 (+) 1137 WP_096753738.1 DNA polymerase III subunit beta -
  CO686_RS09160 (CO686_09160) - 1868627..1868821 (+) 195 WP_000285184.1 DUF951 family protein -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 41998.80 Da        Isoelectric Point: 6.3580

>NTDB_id=247892 CO686_RS09140 WP_000681804.1 1863676..1864872(+) (htrA) [Streptococcus oralis strain FDAARGOS_367]
MKHLQKFYKKGVKVLIIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSGDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=247892 CO686_RS09140 WP_000681804.1 1863676..1864872(+) (htrA) [Streptococcus oralis strain FDAARGOS_367]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAATAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACGAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAAAATGAAAACTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGATGACACTAACTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTCATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATCCGCTTAGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTGGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATCCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTC
CTGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGACAAAGAGATTGCCTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTGGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(217-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.668

100

0.837
  htrA Streptococcus pneumoniae Rx1

82.915

100

0.829
  htrA Streptococcus pneumoniae D39

82.915

100

0.829
  htrA Streptococcus pneumoniae R6

82.915

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.915

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

66.915

100

0.676
  htrA Streptococcus mutans UA159

54.569

98.995

0.54

Multiple sequence alignment