Detailed information NTG0223162

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: A6J85_RS03885
• Genome accession: NZ_CP020450
• Coordinates: 790513..791280 (+)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain FDAARGOS_257
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 785513..796280

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J85_RS03855 (A6J85_03815)	spo0J	785996..786760 (-)	765	WP_008808036.1	ParB/RepB/Spo0J family partition protein	Regulator
A6J85_RS03860 (A6J85_03820)	htrA	786826..788019 (-)	1194	WP_008808035.1	S1C family serine protease	Regulator
A6J85_RS03865 (A6J85_03825)	rlmH	788213..788692 (+)	480	WP_008808034.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
A6J85_RS03875 (A6J85_03835)	comC/comC1	788978..789142 (+)	165	WP_080998577.1	bacteriocin	Regulator
A6J85_RS03880 (A6J85_03840)	comD/comD1	789158..790516 (+)	1359	WP_081102626.1	competence system sensor histidine kinase ComD	Regulator
A6J85_RS03885 (A6J85_03845)	comE/comE2	790513..791280 (+)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
A6J85_RS03900 (A6J85_03860)	ychF	791602..792717 (+)	1116	WP_061586345.1	redox-regulated ATPase YchF	-
A6J85_RS03905 (A6J85_03865)	pth	792791..793360 (+)	570	WP_060970646.1	aminoacyl-tRNA hydrolase	-

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=223162 A6J85_RS03885 WP_008808031.1 790513..791280(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_257]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=223162 A6J85_RS03885 WP_008808031.1 790513..791280(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_257]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGTATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGGGATATTCTATAT
ATTGAGACTACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACTATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361