Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   A6J85_RS03860 Genome accession   NZ_CP020450
Coordinates   786826..788019 (-) Length   397 a.a.
NCBI ID   WP_008808035.1    Uniprot ID   A0AB35FPK4
Organism   Streptococcus gordonii strain FDAARGOS_257     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 781826..793019
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J85_RS03835 (A6J85_03795) - 782408..782926 (+) 519 WP_020992856.1 YehR family protein -
  A6J85_RS03840 (A6J85_03800) - 782945..783148 (-) 204 WP_008808039.1 DUF951 domain-containing protein -
  A6J85_RS03845 (A6J85_03805) dnaN 783148..784284 (-) 1137 WP_008808038.1 DNA polymerase III subunit beta -
  A6J85_RS03850 (A6J85_03810) dnaA 784440..785792 (-) 1353 WP_008808037.1 chromosomal replication initiator protein DnaA -
  A6J85_RS03855 (A6J85_03815) spo0J 785996..786760 (-) 765 WP_008808036.1 ParB/RepB/Spo0J family partition protein Regulator
  A6J85_RS03860 (A6J85_03820) htrA 786826..788019 (-) 1194 WP_008808035.1 S1C family serine protease Regulator
  A6J85_RS03865 (A6J85_03825) rlmH 788213..788692 (+) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  A6J85_RS03875 (A6J85_03835) comC/comC1 788978..789142 (+) 165 WP_080998577.1 bacteriocin Regulator
  A6J85_RS03880 (A6J85_03840) comD/comD1 789158..790516 (+) 1359 WP_081102626.1 competence system sensor histidine kinase ComD Regulator
  A6J85_RS03885 (A6J85_03845) comE/comE2 790513..791280 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  A6J85_RS03900 (A6J85_03860) ychF 791602..792717 (+) 1116 WP_061586345.1 redox-regulated ATPase YchF -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42225.90 Da        Isoelectric Point: 5.4898

>NTDB_id=223159 A6J85_RS03860 WP_008808035.1 786826..788019(-) (htrA) [Streptococcus gordonii strain FDAARGOS_257]
MKNSSNFFKKTLQIFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTVTTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDTIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=223159 A6J85_RS03860 WP_008808035.1 786826..788019(-) (htrA) [Streptococcus gordonii strain FDAARGOS_257]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAATTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAGTAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGATGCTGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCGGATACTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGTGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAGGTTAAAAATGTAGCAGAATTTGGAGATTCTAGTAAATTAACCGTTGGAGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGTTCTGATTATGCTAATACAGTAACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACCCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAAGGTAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCTC
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(236-391)

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.992

100

0.99
  htrA Streptococcus mitis NCTC 12261

66.08

100

0.662
  htrA Streptococcus pneumoniae Rx1

66.162

99.748

0.66
  htrA Streptococcus pneumoniae D39

66.162

99.748

0.66
  htrA Streptococcus pneumoniae R6

66.162

99.748

0.66
  htrA Streptococcus pneumoniae TIGR4

66.162

99.748

0.66
  htrA Streptococcus mutans UA159

56.391

100

0.567

Multiple sequence alignment