Detailed information NTG0223004

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: A6J72_RS05435
• Genome accession: NZ_CP020433
• Coordinates: 1093011..1093760 (+)
• Length: 249 a.a.
• NCBI ID: WP_003075488.1
• Uniprot ID: T1ZH01
• Organism: Streptococcus intermedius strain FDAARGOS_233
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1088011..1098760

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J72_RS05405 (A6J72_05420)	spo0J	1088551..1089318 (-)	768	WP_009569741.1	ParB/RepB/Spo0J family partition protein	Regulator
A6J72_RS05410 (A6J72_05425)	htrA	1089373..1090563 (-)	1191	WP_009569739.1	S1C family serine protease	Regulator
A6J72_RS05415 (A6J72_05430)	rlmH	1090767..1091246 (+)	480	WP_082311948.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
A6J72_RS05425 (A6J72_05440)	-	1091523..1091669 (+)	147	WP_003075491.1	bacteriocin	-
A6J72_RS05430 (A6J72_05445)	comD/comD1	1091686..1093011 (+)	1326	WP_216641942.1	GHKL domain-containing protein	Regulator
A6J72_RS05435 (A6J72_05450)	comE	1093011..1093760 (+)	750	WP_003075488.1	competence system response regulator transcription factor ComE	Regulator
A6J72_RS05450 (A6J72_05465)	-	1094084..1096660 (-)	2577	WP_082311949.1	YfhO family protein	-
A6J72_RS05455 (A6J72_05470)	-	1096734..1098356 (-)	1623	WP_003075484.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29207.78 Da
• Isoelectric Point: 8.0443

>NTDB_id=223004 A6J72_RS05435 WP_003075488.1 1093011..1093760(+) (comE) [Streptococcus intermedius strain FDAARGOS_233]
MKVLVLEDEISHQVRMETTLAEIAKEMGISIKVKVTGKIREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETQRFFSPHKSYLVNIGNIKSYDKKMKEIIFYEDHRCPITRMKIGKL
KTILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=223004 A6J72_RS05435 WP_003075488.1 1093011..1093760(+) (comE) [Streptococcus intermedius strain FDAARGOS_233]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAGAT
GGGAATTTCTATCAAAGTTAAAGTAACTGGAAAAATAAGAGAATTTAAAGAATATATTGAGAATGATGAAGTAAATCAAT
TATACTTTTTAGATATTGATATTAAAGGGGAAGAGACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCATAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACTATGACTTTTAAATATAAAGTTTCTGCACTAGATTT
TGTTGATAAAAATTTGAATGATGTTGCTTTTAAAAAACATATAAAAGATAGCATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTTCGTGGTGGAGAAGTTAGAATGCCATTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTAGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGACAAGGAGACACAGCGTTTCTTTTCACCTCATAAATCTTATTTAGTTAATATTGGAAATATTAAGA
GTTATGACAAAAAAATGAAAGAAATTATTTTTTATGAAGATCACCGTTGCCCGATTACTCGAATGAAAATTGGAAAGTTG
AAAACTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: T1ZH01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	71.311	97.992	0.699
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	71.311	97.992	0.699
comE	Streptococcus infantis strain Atu-4	70.612	98.394	0.695
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.161	100	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361